Epidemiology of brucellosis and Q fever in linked human and animal populations in northern Togo (Publications)
seropositivity amongst village cattle (9.2%, 95%CI:4.3-18.6%) and transhumant cattle (7.3%, 95%CI:3.5-14.7%), with an absence of seropositive small ruminants. Exposure of livestock and people to C. burnetii [...] greater livestock contact and a significantly higher seroprevalence than other ethnic groups (Fulani: 45.5%, 95%CI:37.7-53.6%; non-Fulani: 27.1%, 95%CI:20.6-34.7%). Appropriate diagnostic test cut-off values
Comparative genomics of the anopheline glutathione s-transferase epsilon cluster (Publications)
analysis and protein modelling gave evidence for positive selection on codons of the catalytic site in GSTE5 albeit its origin seems to predate the introduction of chemical insecticides. Gene expression profiles [...] World Cellia subgenus, instead of a secondary loss. The modifications of the catalytic site within GSTE5 may represent adaptations to new habitats
Determinants of virological failure and antiretroviral drug resistance in Mozambique (Publications)
III/IV [OR = 2.10 (95% CI = 1.23-3.57), P = 0.003] and low ART adherence [OR = 2.69 (95% CI = 1.39-5.19), P = 0.003] were associated with virological failure. Longer time on ART [OR = 1.55 per additional [...] clinical and immunological outcomes, only achieved 29% sensitivity and misdiagnosed 1 out of every 4.5 subjects. CONCLUSIONS: Public health programmes in Mozambique should focus on early HIV diagnosis, early
Perceived illness drives participation in mass deworming campaigns in Laos (Publications)
(19/21). Most leaders (20/21) had a good knowledge on severe schistosomiasis though only a few of them (5/21) described its cause correctly. They knew little about the disease consequences of liver fluke (3/21) [...] fish (100%), frequent physical contacts with Mekong River water (76.0%) and low number of latrines (14.5%). In conclusion, MDA is widely accepted in affected communities. Avoiding severe schistosomiasis was
Land use regression models for estimating individual NOx and NO2 exposures in a metropolis with a high density of traffic roads and population (Publications)
stepwise multiple regressions. The annual average concentrations of NOx and NO2 in Taipei were 72.4 +/- 22.5 and 48.9 +/- 12.2 mug/m(3), respectively, which were at the high end of all 36 European areas in the [...] were lengths of major roads within 25 m, 25-50 m, and 50-500 m, urban green areas within 300 m and 300-5,000 m, and semi-natural and forested areas within 500 m, with R(2)=0.81. The NO2 LUR model included
Countdown to 2015: tracking donor assistance to maternal, newborn, and child health (Publications)
mortality and ODA per head, although at any given rate of mortality for children aged younger than 5 years or maternal mortality, there is significant variation in the amount of ODA per person received [...] If commitments are to be honoured, global aid flows will need to increase sharply during the next 5 years. The challenge will be to ensure a sufficient share of these new funds is channelled effectively
Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric fixed-dose combination tablets (Publications)
malnourished. Mean (range) nevirapine C12h, Cmax and AUC12h of 6.0 (1.4, 16.9) mg/l, 10.0 (3.8, 22.5) mg/l and 94.4 (32.1, 232) mg/l per hour were higher than those reported in adults. Nevirapine C12h [...] lamivudine C12h, Cmax, AUC12h ( < 0.015 mg/l, 0.45 mg/l, 1.05 mg/l per hour and 0.09 mg/l, 1.33 mg/l, 5.42 mg/l per hour) were comparable to adults. There was no evidence of a difference in nevirapine AUC12h
Bridging the gap: how traditional healers interact with their patients. A comparative study in Cameroon (Publications)
except for age, where TH patients were on average 9 years younger (P < 0.05). Patients of TH travelled 2.5 times as far to their provider as did patients in the WP group (79 vs. 31 km; P < 0.05) and paid 12 [...] 12 times more for their treatment (123 vs. 10 Euros; P < 0.05). Consultations of TH were shorter (5.6 vs. 10.3 min, P < 0.01), had fewer utterances (100 vs. 166, P < 0.05) and the patient's share in the
Safety and immunogenicity of H1/IC31(R), an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350... (Publications)
s were enrolled and followed until day 182. H1/IC31 vaccine or placebo was randomly allocated in a 5ratio1 ratio. The vaccine was administered intramuscularly at day 0 and 56. Safety assessment was based [...] Local injection site reactions were more common in H1/IC31 versus placebo recipients (65.0% vs. 12.5%, p = 0.015). Solicited systemic and unsolicited adverse events were similar by study arm. The baseline
Health-related quality of life among school children with parasitic infections: findings from a national cross-sectional survey in Côte d'Ivoire (Publications)
848 children aged 5-16 years revealed Plasmodium spp., hookworm, Schistosoma haematobium, Schistosoma mansoni, Ascaris lumbricoides, and Trichuris trichiura prevalences of 75.0%, 17.2%, 5.7%, 3.7%, 1.8%,