Repeated cross-sectional skin testing for bovine tuberculosis in cattle kept in a traditional husbandry system in Ethiopia (Publications)
cent). Due to the low apparent prevalence, the true prevalence could be calculated only in Meskan (4.5 per cent) and Bako-Gazer (2.4 per cent) for the more than 2 mm cut-off. With the exception of Meskan [...] per cent CI 1.4 to 2.6, respectively), as were animals in good body condition (OR 2, 95 per cent CI 1.5 to 2.9). Similar results were found at woreda level with the exception of Woldia, where none of the
Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of turkish medicinal plants (Publications)
potent antiplasmodial activity was observed with the CHCl(3) extracts of Phlomis kurdica (IC(50) 1.5 microg[sol ]mL), P. leucophracta (IC(50) 1.6 microg[sol ]mL), Scrophularia cryptophila (IC(50) 1.8 [...] (IC(50) 1.6 microg[sol ]mL). Twenty-one extracts with significant antimalarial activity (IC(50) < 5 microg[sol ]mL) were also tested for their ability to inhibit the purified enoyl-ACP reductase (FabI)
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants (Publications)
candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants 6 to 12 weeks [...] confidence interval [CI], 23.6 to 36.1). Vaccine efficacy in the per-protocol population was 31.3% (97.5% CI, 23.6 to 38.3). Vaccine efficacy against severe malaria was 26.0% (95% CI, -7.4 to 48.6) in the
Maternal mortality and distance to facility-based obstetric care in rural southern Tanzania: a secondary analysis of cross-sectional census data in... (Publications)
to distance, with mortality increasing from 111 per 100?000 livebirths among women who lived within 5 km to 422 deaths per 100?000 livebirths among those who lived more than 35 km from a hospital (adjusted [...] indirect maternal mortality was associated with distance to hospital. Among women who lived within 5 km of a hospital, pregnancy-related mortality was 664 deaths per 100?000 livebirths even though 72%
Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
and acquired immunity, entail a partial rebound in malaria mortality among people above 5 years of age from around 5-7 years following scale-up. SMC does not reduce endemicity, but slightly shifts malaria
The prevalence of brucellosis and bovine tuberculosis in ruminants in Sidi Kacem Province, Morocco (Publications)
of brucellosis in cattle at individual and herd level was 1.9% (95% CI 1.2%-2.8%) and 9% (95% CI 4.5%-1.5%), respectively. Brucella pathogens were isolated from three cattle milk samples and were identified
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing (Publications)
for veterinary trypanosomosis. In all kinetoplastids, transcription is polycistronic. Individual mRNA 5'-ends are created by trans splicing of a short leader sequence, with coupled polyadenylation of the [...] not, however, always correlate and prolonged selection of trypanosomes in AN7973 resulted in only 1.5-fold resistance. It is therefore possible that the modes of action of oxaboroles that target trypanosome
Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania (Publications)
from 0 to 76.4% among councils. The malaria prevalence was below 5% in 62 of the 166 councils and above 50% in 18 councils and between 5 and 50% in the other councils. The variation of malaria prevalence
High genetic diversity in the <em>Dirofilaria repens</em> species complex revealed by mitochondrial genomes of feline microfilaria samples from... (Publications)
the closely related species Candidatus Dirofilaria hongkongensis was proposed. Previous analysis of 2.5 kb partial mitochondrial genome sequences containing the particularly variable non-coding control region [...] distance between the valid sibling species Onchocerca volvulus and Onchocerca ochengi. Sequencing of a 2.5 kb fragment containing the control region from microfilarial DNA from additional feline blood samples
High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - a prospective cohort study (Publications)
Additionally, viral load was measured before start of protease inhibitor, a second time between 1-5 years after start, and at suspected treatment failure in patients with available bio-banked samples [...] of resistance mutations for protease inhibitors were seen at this time. In samples taken between 1-5 years protease inhibitor resistance was demonstrated in 2/7 adults. In adult samples before protease