The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing (Publications)
for veterinary trypanosomosis. In all kinetoplastids, transcription is polycistronic. Individual mRNA 5'-ends are created by trans splicing of a short leader sequence, with coupled polyadenylation of the [...] not, however, always correlate and prolonged selection of trypanosomes in AN7973 resulted in only 1.5-fold resistance. It is therefore possible that the modes of action of oxaboroles that target trypanosome
High genetic diversity in the <em>Dirofilaria repens</em> species complex revealed by mitochondrial genomes of feline microfilaria samples from... (Publications)
the closely related species Candidatus Dirofilaria hongkongensis was proposed. Previous analysis of 2.5 kb partial mitochondrial genome sequences containing the particularly variable non-coding control region [...] distance between the valid sibling species Onchocerca volvulus and Onchocerca ochengi. Sequencing of a 2.5 kb fragment containing the control region from microfilarial DNA from additional feline blood samples
Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease... (Publications)
of 28.2% (27.8-28.5) and 1.50 billion (1.48-1.52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries
Respiratory and allergic outcomes among farmworkers exposed to pesticides in Costa Rica (Publications)
concentrations of 15 pesticide biomarkers measured in urine samples collected during two visits (4-5 weeks apart). We fitted "traditional" Bayesian and Bayesian Weighted Quantile Sum (BWQS) regression [...] 1.67), and rhinitis (aOR = 1.34; 95 % CrI: 1.15, 1.56). Higher urinary concentrations of boscalid-5-hydroxy (metabolite of fungicide boscalid) were associated with increased odds of asthma symptoms or
High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - a prospective cohort study (Publications)
Additionally, viral load was measured before start of protease inhibitor, a second time between 1-5 years after start, and at suspected treatment failure in patients with available bio-banked samples [...] of resistance mutations for protease inhibitors were seen at this time. In samples taken between 1-5 years protease inhibitor resistance was demonstrated in 2/7 adults. In adult samples before protease
Contextual factors influencing schistosomiasis treatment and identification of delivery platforms for arpraziquantel in hard-to-reach areas and... (Publications)
parents/caregivers living with disability caring for children ≤5 years,18 focus group discussions (FGDs) with parents/caregivers of children ≤5 years (each with 8-10 participants), 14 key informant interviews
Spatiotemporal modelling of airborne birch and grass pollen concentration across Switzerland: a comparison of statistical, machine learning and... (Publications)
these six models through multiple linear regression to develop an ensemble hybrid model. RESULTS: The 5(th)-95(th) percentiles of birch and grass pollen concentrations were 0-151 and 0-105 grains/m(3), r [...] linear models (LASSO, Ridge, Elastic net) for both pollen types, with RMSE's ranging from 105.9 to 140.5 grains/m(3) for birch and from 20 to 25.4 grains/m(3) for grass pollen. The Random forest algorithm
Efficacy and safety of ascending dosages of albendazole against <em>Trichuris trichiura</em> in preschool-aged children, school-aged children and... (Publications)
PSAC was 27.8% (95% CI: 9.7%-53.5%) in the 600 mg albendazole treatment arm. The most efficacious arm for SAC was 600 mg of albendazole showing a CR of 25.6% (95% CI: 13.5%-41.2%), and for adults it was
Investigating the drivers of the spatio-temporal patterns of genetic differences between <em>Plasmodium falciparum</em> malaria infections in Kilifi... (Publications)
geographic distance between parent and offspring malaria infections for the base model was 0.5 km (95% CI 0.3-1.5), for a distribution with 68% of distances shorter than the mean. Very short mean distances
Accounting for MOBility in AIR pollution exposure estimates in studies on long-term health effects. (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/accounting-for-mobility-in-air-pollution-exposure-estimates-in-studies-on-long-term-health-effects
existing air pollution exposure models, and will include these traffic-related pollutants: NO2, BC, PM2.5, PM2.5 elemental composition and UFP. These existing models will be enhanced to produce long-term hourly
