Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from... (Publications)
the Chinese liana Ancistrocladus tectorius (Ancistrocladaceae), two new 5,8'-coupled naphthylisoquinolines, ancistectorine D (5) and its 6-O-demethyl derivative 6, were isolated, along with two new 7,1'-linked [...] (oxidative degradation) and chiroptical (circular dichroism) methods. Chemotaxonomically remarkable, 5,8'-coupled naphthylisoquinolines have as yet been found quite rarely in Asian Ancistrocladus species [...] coupling type represent the by far the largest group of constituents in...
Knowledge and practices of mothers and caregivers on diarrhoeal management among under 5-year-old children in a medium-size town of Senegal (Publications)
under 5 years of age were included. Slightly less than a quarter (23.2%, 95% confidence interval (CI) 18.9-27.8%) of respondents had good management practice of diarrhoea, while 40.0% (95% CI: 34.5-45.6%) [...] study assessed knowledge and practices of mothers and caregivers on diarrhoeal management among under 5-year-old children in a medium-size town of Senegal. A cross-sectional survey was carried out between [...] located in the south-western part of Senegal. Mothers and caregivers of...
Estimation of daily PM10 and PM2.5 concentrations in Italy, 2013-2015, using a spatiotemporal land-use random-forest model (Publications)
Particulate matter (PM) air pollution is one of the major causes of death worldwide, with demonstrated adverse effects from both short-term and long-term exposure. Most of the epidemiological studies
Low sensitivity of the MPT64 identification test to detect lineage 5 of the <em>Mycobacterium tuberculosis</em> complex (Publications)
the rapid MPT64 antigen identification test for the detection of Mycobacterium africanum lineage 5 (MAF L5). METHODOLOGY: Smear-positive tuberculosis patients' sputa were included prospectively. Culture [...] MTBc isolates (93.2 %, 300/322), but it failed to detect 24 % of the L5 isolates (18/75) versus 2 % (4/202) of the L4 ones [OR=15.6 (5.3-45.8), P
Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm (Publications)
of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1 H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 muM. Medicinal chemistry optimization targeted modifications
Validation of <em>Plasmodium falciparum</em> dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity (Publications)
and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5'-triphosphate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within [...] construct could recombine correctly in the locus suggesting that the enzyme is essential. The four 5'-tritylated deoxyuridine analogues described are potent inhibitors of the P. falciparum dUTPase and
Antibiotic exposure among children younger than 5 years in low-income and middle-income countries: a cross-sectional study of nationally... (Publications)
to quantify antibiotic exposure in children younger than 5 years in LMICs. METHODS: We did a cross-sectional study in sick children younger than 5 years who attended a health-care facility in eight LMICs [...] exposure in children from birth up to age 5 years in each LMIC. FINDINGS: From SPA surveys, we identified 22 519 clinical observations of children younger than 5 years who visited a health-care facility [...] prescribed to 80.5% of children diagnosed with respiratory illness, 50.1% with...
Comparison of next-generation portable pollution monitors to measure exposure to PM2.5 from household air pollution in Puno, Peru (Publications)
exposure to PM2.5 is critical for understanding intervention effectiveness and exposure-response relationships in household air pollution studies. In this pilot study, we compared PM2.5 concentrations obtained
Bayesian conditional autoregressive models to assess spatial patterns of diarrhoea risk among children under the age of 5 years in Mbour, Senegal. (Publications)
were analysed to describe the spatial pattern of diarrhoeal prevalence in children under the age of 5 years in the secondary city of Mbour in the south-western part of Senegal. Bayesian conditional aut
National and sub-national exposure to ambient fine particulate matter PM2.5 and its attributable burden of disease in Iran from 1990 to 2016 (Publications)
Ambient particulate matter is a public health concern. We aimed (1) to estimate national and provincial long-term exposure of Iranians to ambient particulate matter (PM)