Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (Review) (Publications)
all-cause mortality, both overall (risk ratio (RR) 0.89, 95% confidence interval (CI) 0.75 to 1.05; 5 RCTs, 9932 participants, moderate-certainty evidence), and restricted to studies with six-month follow-up [...] mortality in participants known to be infected with HIV (odds ratio (OR) 0.80, 95% CI 0.67 to 0.96; 5 RCTs, 5855 participants; moderate-certainty evidence). It is uncertain whether Xpert MTB/RIF has no [...] on the proportion of participants who were treated for tuberculosis (RR 1.10,...
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Rutaceae. Nectandrin B exhibited the highest activity against L. donovani (IC50 4.5 µM) and the highest selectivity index (25.5). Given the urgent need for better drugs and the fact that mycetoma is the most [...] From this screening, niclosamide showed interesting activity with a minimal inhibitory concentration ˂5 µM. Furthermore, additional niclosamide analogues were tested for proof of concept. The tested compounds
Report actuelles (Page)
https://www.swisstph.ch/fr/projects/ludok/aktuelle-berichte
quelles sont les conséquences sanitaires de la pollution et quel est le niveau de conformité. En plus des 5 polluants classiques, le rapport considère également les PUNR, la suie, et d'autres polluants réglementés [...] Le projet GeLuft a calculé en parallèle que le respect des valeurs indicatives de l'OMS pour les PM2.5 et le NO2 en Suisse permettrait d'éviter plus de 3300 décès prématurés et 3400 cas d'asthme par rapport [...] Meta-analysis of selected health effects of long-term exposure to...
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Rutaceae. Nectandrin B exhibited the highest activity against L. donovani (IC50 4.5 µM) and the highest selectivity index (25.5). Given the urgent need for better drugs and the fact that mycetoma is the most [...] From this screening, niclosamide showed interesting activity with a minimal inhibitory concentration ˂5 µM. Furthermore, additional niclosamide analogues were tested for proof of concept. The tested compounds
Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (Review) (Publications)
all-cause mortality, both overall (risk ratio (RR) 0.89, 95% confidence interval (CI) 0.75 to 1.05; 5 RCTs, 9932 participants, moderate-certainty evidence), and restricted to studies with six-month follow-up [...] mortality in participants known to be infected with HIV (odds ratio (OR) 0.80, 95% CI 0.67 to 0.96; 5 RCTs, 5855 participants; moderate-certainty evidence). It is uncertain whether Xpert MTB/RIF has no [...] on the proportion of participants who were treated for tuberculosis (RR 1.10,...
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
and late development of Plasmodium falciparum gametocytes in vitro in a dose dependent fashion over a 5-500 nM range. In addition, using the standard membrane feeding assay, NITD609 was also found to be a
Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium <em>Lyngbya majuscula</em> (Publications)
potent cytotoxic activity against P388 murine leukemia cell lines, with IC(50) values of 6.4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities
Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland (Publications)
detection method was validated and evaluated in a series of field studies. G. lamblia was detected in 97.5% of surface water samples taken from two streams (Birs and Ergolz) located in the canton Basel-Landschaft
ST2859 serogroup A meningococcal meningitis outbreak in Nouna Health District, Burkina Faso: a prospective study (Publications)
Faso, during the meningitis seasons of 2004-2006. Serogroup A ST2859 meningococci belonging to the ST5 clonal complex of subgroup III meningococci were the predominant causative agent. ST2859 bacteria were
The burden of heat-related mortality attributable to recent human-induced climate change (Publications)
ced warming, during the period 1991–2018. Across all study countries, we find that 37.0% (range 20.5–76.3%) of warm-season heat-related deaths can be attributed to anthropogenic climate change and that