Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action [Communication] (Publications)
B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most
Training in flexible intensive insulin therapy improves quality of life, decreases the risk of hypoglycaemia and ameliorates poor metabolic control in... (Publications)
METHODS: We prospectively followed 45 type 1 diabetic patients of our outpatient clinic participating in 5 consecutive FIT teaching courses at the University Hospital of Basel. These courses consist of 7 weekly
Limonoid orthoacetates and antiprotozoal compounds from the roots of<em> Pseudocedrela kotschyi</em> (Publications)
(1-3), named kotschyins A-C, and the known compounds 7-deacetylgedunin (4) and 7-deacetyl-7-oxogedunin (5). The structures of 1-3 were elucidated by analytical methods including 1D- and 2D-NMR spectroscopy
Tests diagnostiques rapides (TDR): la panacée pour le praticien? (Publications)
aimed at interrupting the transmission of the disease, (4) avoiding useless antibiotic treatments and (5) implementing a sequential diagnostic strategy to avoid extensive investigations. Using the example
Antitrypanosomal quinoline alkaloids from the roots of <em>Waltheria indica</em> (Publications)
the isolated constituents were evaluated for their in vitro antitrypanosomal activity. Compounds 4, 5, and 8 showed potent and selective growth inhibition toward Trypanosoma cruzi with IC50 values between
Trypanocidal activity of diarylheptanoids from <em>Schrankia leptocarpa</em> DC (Publications)
leptocarpa DC. (Mimosaceae) led to the isolation of two diarylheptanoids (1-2), three phenolic acid (3-5), one p-coumaric acid derivate (6) and three flavonoids (7-9). The structures of the isolated compounds
Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium <em>Lyngbya majuscula</em> (Publications)
potent cytotoxic activity against P388 murine leukemia cell lines, with IC(50) values of 6.4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
and late development of Plasmodium falciparum gametocytes in vitro in a dose dependent fashion over a 5-500 nM range. In addition, using the standard membrane feeding assay, NITD609 was also found to be a
ST2859 serogroup A meningococcal meningitis outbreak in Nouna Health District, Burkina Faso: a prospective study (Publications)
Faso, during the meningitis seasons of 2004-2006. Serogroup A ST2859 meningococci belonging to the ST5 clonal complex of subgroup III meningococci were the predominant causative agent. ST2859 bacteria were
Occurrence of <em>Giardia lamblia</em> in recreational streams in Basel-Landschaft, Switzerland (Publications)
detection method was validated and evaluated in a series of field studies. G. lamblia was detected in 97.5% of surface water samples taken from two streams (Birs and Ergolz) located in the canton Basel-Landschaft