The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone (Publications)
An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures [...] structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-membered rings in classical chair conformations. As polarity in the tetraoxane series increased, in vitro
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus <em>Trypanosoma cruzi</em> and <em>Leishmania donovani</em> (Publications)
The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active comp
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years (Publications)
BACKGROUND & AIMS: Primary eosinophilic esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus. The leading symptom in adults is uniform attacks of dysphagia
Source apportionment of ambient PM2.5 at five spanish centres of the european community respiratory health survey (ECRHS II) (Publications)
clearly observed in PM2.5. Multi-linear regression analysis (MLRA) was applied to the data, showing that traffic was the main source of PM2.5 at the five sites (39-53% of PM2.5, 5.1-12.0 mgm [...] particulate matter (PM2.5) was sampled at 5 Spanish locations during the European Community Respiratory Health Survey II (ECRHS II). In an attempt to identify and quantify PM2.5 sources, source contribution [...] analysis (PCA) was performed on five datasets containing elemental composition of PM2.5...
Associations between infections and clinical outcome parameters in status epilepticus: a retrospective 5-year cohort study (Publications)
ICU stay (p = 0.0041), higher risk of RSE (odds ratio [OR] 4.8, p = 0.0002), and higher mortality (OR 5.2, p = 0.0003) than those without infectious complications. Infections during the first 3 days after
Levels of physical activity and sedentary time among 10- to 12-year-old boys and girls across 5 European countries using accelerometers: an... (Publications)
ABSTRACT: BACKGROUND: The study aim was to objectively assess levels of sedentary time, light, moderate and vigorous physical activity (PA) among 10-12 year olds across five European countries and to