Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (Publications)
up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1),
Arylmethylamino steroids as antiparasitic agents (Publications)
intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of 1o drastically
Current status of schistosomiasis and soil-transmitted helminthiasis in Beyla and Macenta Prefectures, Forest Guinea (Publications)
(epg) for Schistosoma mansoni, 21.0% and 17.8 eggs per 10ml of urine for S. haematobium, 51.2% and 507.5 epg for hookworm, 8.1% and 89.1 epg for Ascaris lumbricoides and 2.4% and 16.7 epg for Trichuris trichiura
Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids (Publications)
pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and jasmolin I (5)] from this extract. These were tested together with 15 synthetic pyrethroids for their activity against
Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study (Publications)
PI-based regimen by 31st December 2016 with a median follow-up time of 26 months (IQR 24-36). Overall, 92.5% of patients were retained in care; 83% achieved VL
Rating early child development outcome measurement tools for routine health programme use (Publications)
tions, Assessment, Development and Evaluations. RESULTS: 61 tools were initially identified, 8% (n=5) population-level and 92% (n=56) individual-level screening or ability tests. Of these, 27 tools covering
Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives (Publications)
against the chloroquine- and pyrimethamine-resistant K1 strain of P. falciparum (IC50 range, 0.17 to 5 microM). In addition, seven compounds displayed activity against intracellular T. cruzi amastigotes
Antimalarial beta-carbolines from the New Zealand ascidian<em> Pseudodistoma opacum</em> (Publications)
activity toward a chloroquine-resistant strain of Plasmodium falciparum, with an IC(50) range of 2.5-14 muM. The biosynthesis of 1-4 is proposed to proceed via a Pictet-Spengler condensation of 6-brom
<em>Dipetalonema viteae</em> (Filarioidea): development of the infective larvae in vitro (Publications)
isolated from ticks. The larvae could complete their third moult and grew on a fourth stage larvae up to 5 mm. This development was comparable to that observed in vivo. The presence of an irradiated hamster
Assessment of breast cancer opportunistic screening by clinical-pathological indicators: a population-based study (Publications)
breast cancer were identified. The proportion of DCIS with respect to invasive cases increased from 5.8% in the period 1996-2001 to 6.4% in the period 2002-2007. The median tumour size of invasive cancers