Prodrugs of reverse fosmidomycin analogues (Publications)
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been used
Assessment of breast cancer opportunistic screening by clinical-pathological indicators: a population-based study (Publications)
breast cancer were identified. The proportion of DCIS with respect to invasive cases increased from 5.8% in the period 1996-2001 to 6.4% in the period 2002-2007. The median tumour size of invasive cancers
<em>Dipetalonema viteae</em> (Filarioidea): development of the infective larvae in vitro (Publications)
isolated from ticks. The larvae could complete their third moult and grew on a fourth stage larvae up to 5 mm. This development was comparable to that observed in vivo. The presence of an irradiated hamster
Growth losses in Swiss forests caused by ozone: epidemiological data analysis of stem increment of <em>Fagus sylvatica L.</em> and <em>Picea... (Publications)
forest growth losses by ozone on a country-wide scale. For Switzerland, these estimates amount to 19.5% growth reduction for deciduous forests, 6.6% for coniferous forests and 11.0% for all forested areas
Monitoring of larval habitats and mosquito densities in the Sudan savanna of Mali: implications for malaria vector control (Publications)
season mosquito breeding population in and near the village of Bancoumana, Mali, and in a fishing hamlet 5 km from this village and adjacent to the Niger River. In Bancoumana, most larval habitats were human
Substituted 2-phenyl-imidazopyridines: a new class of drug leads for human African trypanosomiasis (Publications)
exposure in mice. Compound 87 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg. Given its potent anti-parasitic properties and its ease of synthesis, compound 87 represents
Antiprotozoal screening of 60 south African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II (Publications)
from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC50 values of 0.9, 1.5, and 0.23 microM, respectively
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes (Publications)
activity against T. b. rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5mg/kgx4 days
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (Publications)
up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1),
Rating early child development outcome measurement tools for routine health programme use (Publications)
tions, Assessment, Development and Evaluations. RESULTS: 61 tools were initially identified, 8% (n=5) population-level and 92% (n=56) individual-level screening or ability tests. Of these, 27 tools covering