Treatment with coartem (artemether-lumefantrine) in Papua New Guinea (Publications)
(artemether-lumefantrine) to be highly effective against Plasmodium falciparum in children less than 5 years of age in Papua New Guinea (PNG). In contrast, we have observed high levels of treatment failures
Compliance with focused antenatal care services: do health workers in rural Burkina Faso, Uganda and Tanzania perform all ANC procedures? (Publications)
three African countries. This descriptive observational study took place in HF in Nouna, Burkina Faso (5), Iganga, Uganda (6) and Rufiji, Tanzania (7). In total, 788 ANC sessions and service provisions were
Preparedness of anesthesiologists working in humanitarian disasters (Publications)
should improve preparedness for anesthesia personnel. (Disaster Med Public Health Preparedness. 2013;0;1-5).
1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro (Publications)
activity at low micromolar concentrations, with varied degrees of selectivity against L-6 cells. Compound 5a was found to be the most active against P. falciparum, with an IC50 value of 90 nM and good selectivity
Identification and characterization of the three members of the CLC family of anion transport proteins in<em> Trypanosoma brucei</em> (Publications)
currents. Currents are sensitive to low concentrations of DIDS, insensitive to the pH in the range 5.4 to 8.4 and larger in nitrate than in chloride medium.
<em>Schistosoma mansoni</em> in schoolchildren in a Madagascan highland school assessed by PCR and sedimentation microscopy and Bayesian estimation of... (Publications)
Bayesian posterior estimate of the prevalence is 80.2%. Simple sedimentation technique misses about 4/5 of all PCR-confirmed infections and is insufficient to determine the prevalence of S. mansoni. A survey
Prisons as ecological drivers of fitness-compensated multidrug-resistant <em>Mycobacterium tuberculosis</em> (Publications)
l resistance(1). Drug resistance-conferring mutations frequently cause fitness costs in bacteria(2-5). Experimental work indicates that these drug resistance-related fitness costs might be mitigated by
Pyrethroid and etofenprox resistance in <em>Anopheles gambiae </em>and <em>Anopheles coluzzii </em>from vegetable farms in Yaounde, Cameroon:... (Publications)
hrin and etofenprox, using 1x insecticide diagnostic concentrations for resistance incidence, then 5x and 10x concentrations for resistance intensity. Subsamples were analyzed for species identification
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation (Publications)
DNAm at 420,509 DNAm sites in blood. We present a database of > 270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive
Synthesis and biological evaluation of natural-product-inspired, aminoalkyl-substituted 1-benzopyrans as novel antiplasmodial agents (Publications)
distance of the basic amino moiety toward both aromatic rings were varied systematically. 1-Benzopyran-5-ol 8b (IC50 = 10 nM), 1-benzopyran-7-ol 9c (IC50 = 38 nM), and the aminoalcohol 19c (IC50 = 17 nM) displayed
