Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts (Publications)
composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood. METHODS: We analyzed data from 4 European [...] Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to
Exploring RF-EMF levels in Swiss microenvironments: an evaluation of environmental and auto-induced downlink and uplink exposure in the era of 5G (Publications)
Compared to the non-user scenario, exposure levels increased substantially during max DL due to the 5G band at 3.5 GHz with 50% of the median levels between 3.20 and 12.13 mW/m(2), mostly in urban areas. Note [...] to measure environmental, auto-induced downlink (DL), and uplink (UL) RF-EMF exposure in the era of 5G. We present results when applying the protocol in Switzerland. Five study areas with different degrees
Air pollution mixture complexity and its effect on PM2.5-related mortality: a multicountry time-series study in 264 cities (Publications)
oxidative capacity of PM(2.5) or its composition. CONCLUSIONS: The PMCI represents an efficient and simple predictor of local PM(2.5)-related mortality, providing evidence that PM(2.5) toxicity depends on the [...] particulate matter (PM(2.5)) occurs within a mixture of other pollutant gases that interact and impact its composition and toxicity. To characterize the local toxicity of PM(2.5), it is useful to have an [...] evaluate to which extent it relates to PM(2.5) toxicity. METHODS: The PMCI...
Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French... (Publications)
PM(2.5) and NO(2) concentrations during pregnancy were modeled at residential address using land use regression. We assessed associations using logistic regressions per interquartile range (PM(2.5): 3 μg/m(3); [...] associations for PM(2.5) (1.49 (1.03-2.13), p = 0.03) and NO(2) (1.40 (1.08-1.82), p = 0.01) in the urban stratum. At 12-years, main analyses showed a tendency of associations of PM(2.5) (1.38 (0.98-1.93) [...] was to investigate the associations of pregnancy exposure to outdoor fine...
The association of increased pre- and postnatal NO2 and PM2.5 exposure with the infant nasal microbiome composition and respiratory symptoms (Publications)
were 21.54 μg/m(3) (NO(2)) and 13.84 μg/m(3) (PM(2.5)) (WHO guideline limits: NO(2): 40 μg/m(3) (2005), 10 μg/m(3) (2021); PM(2.5): 10 μg/m(3) (2005), 5 μg/m(3) (2021)). We identified two distinct microbiome [...] investigated the association of pre- and postnatal nitrogen dioxide (NO(2)) and particulate matter ≤2.5 μm (PM(2.5)) with microbiome at 4-6 weeks and with respiratory symptoms during the first year of life. H [...] NO(2): odds ratio 1.58, 95% confidence interval 1.08; 2.29, p(adj) =...
Single- and two-pollutant concentration-response functions for PM2.5 and NO2 for quantifying mortality burden in health impact assessments (Publications)
in HIAs, focusing on long-term exposure to particulate matter with a diameter less than 2.5 micrometers (PM(2.5)) and nitrogen dioxide (NO(2)) and their associations with all-cause mortality. METHODS: A [...] 053 (95% confidence interval: 1.034-1.071) and 1.035 (1.014-1.057), respectively, for a 5 μg/m(3) increase in PM(2.5). HRs for a 10 μg/m(3) increase in NO(2) were 1.032 (1.014-1.049) and 1.024 (1.000-1.049) [...] coefficient difference between single- and two-pollutant models was 0.017 for...
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative... (Publications)
the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibition increases the risk [...] against complement components other than C3 and C5 may carry a reduced risk of infection, we compared the effect of inhibitors targeting the terminal pathway (C5), the central complement component C3, the [...] H-binding protein (fHbp). SBA triggered by these cell surface...
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 inflammasome (Publications)
conditions. To uncover the possible therapy for PM(2.5) related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM(2.5) induced lung injury in mice by utilizing the survival [...] findings strongly indicated Sal as an effective precaution against PM(2.5) induced lung injury. Pre-administration of Sal before PM(2.5) treatment reduced the mortality within 120 h and alleviated inflammatory [...] PM(2.5) treatment via regulating Bax/Bcl-2/caspase-3 and...
