Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
METHODS: Double-blinded bioassays were conducted on twenty unused pyrethroid ITNs of 4 brands (100 nets, 5 subsamples per net) that had been delivered for mass distribution in Papua New Guinea (PNG) having passed [...] mortality (M24) (rs = 0.9,p < 0.0001,n = 20) but BA showed systematic bias between the results. Of the 5 nets with discrepant result between IHI and PNGIMR, three had confidence intervals overlapping the 80%
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of <em>Klebsiella oxytoca</em> group in invasive infections: a retrospective... (Publications)
cephalosporins than K. variicola isolates (odds ratio = 2.61, p = 0.003, 95% confidence interval [1.38,5.06]). K. oxytoca group isolates were found to be more likely associated with invasive infection to primary [...] sites than K. pneumoniae group isolates (odds ratio = 2.39, p = 0.0044, 95% confidence interval [1.05,5.53]). CONCLUSIONS: Currently misdiagnosed Klebsiella spp. can be distinguished using a ribosomal ma
Potential contribution of HIV during first-line tuberculosis treatment to subsequent rifampicin-monoresistant tuberculosis and acquired tuberculosis... (Publications)
tuberculosis, HIV positivity during previous treatment (adjusted OR 5.13, 1.61-16.32) was associated with uniqueness as was female sex (2.50 [1.18-5.26]). Interpretation: These data suggest that HIV contributes
Cancer risk in adolescents and young adults living with HIV in South Africa: a nationwide cohort study (Publications)
including 429 who developed Kaposi sarcoma (30.0 per 100 000 person-years), 107 non-Hodgkin lymphoma (7.5 per 100 000 person-years), 48 Hodgkin lymphoma (3.4 per 100 000 person-years), 45 cervical cancer (3 [...] non-Hodgkin lymphoma (3.17, 2.06-4.89), Hodgkin lymphoma (4.83, 2.61-8.93), and leukaemia (unadjusted HR 5.90, 95% CI 2.87-12.12). Cancer rates decreased over the study period, driven by declining Kaposi sarcoma
Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic... (Publications)
27·7 deaths (25·1-29·9) per 100 000. 502 000 deaths (406 000-611 000) were in children younger than 5 years, among which 254 000 deaths (197 000-320 000) occurred in countries with a low Socio-demographic [...] were other viral aetiologies (46·4 million [43·6-49·3] episodes) and Mycoplasma spp (25·3 million [23·5-27·2]), while those responsible for the second and third highest death counts were S aureus (424 000 [...] to 2019, the global all-age non-COVID-19 LRI mortality rate declined by 41·7%...
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease... (Publications)
provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) [...] quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels [...] (NCDs) represented 72.3% (95% uncertainty interval [UI] 71.2-73.2) of...
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease... (Publications)
provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) [...] quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels [...] (NCDs) represented 72.3% (95% uncertainty interval [UI] 71.2-73.2) of...
Implementation of a digital Clinical Decision Support System / ICRC Somalia (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/implementation-of-a-digital-clinical-decision-support-system-/-icrc-somalia
of infant and child mortality are illnesses such as pneumonia (21%), diarrhoea (14%), and measles (5%), as well as neonatal deaths (29%). Owing to insecurity and displacement, over half a million young [...] risk of contracting diseases. To improve the quality of care for children between 2 and 59 months (< 5 years) old in the South-Central Somali region, the International Committee of the Red Cross (ICRC) and [...] intervention, which has the potential to significantly improve the quality of...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
Immunization with PfSPZ Vaccine induced IgG and IgM isotypes specific for the Merozoite surface protein 5 (PfMSP 5) and the circumsporozoite protein (PfCSP) regardless of HIV infection status. Interestingly, volunteers [...] protection since no difference was observed between CHMI protected and non-protected volunteers. Manuscript 5: HIV-1 positive and HIV-1 negative Tanzanian adults undergoing whole irradiation attenuated Plasmodium [...] vaccination mount antibody responses targeting the...
Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
Immunization with PfSPZ Vaccine induced IgG and IgM isotypes specific for the Merozoite surface protein 5 (PfMSP 5) and the circumsporozoite protein (PfCSP) regardless of HIV infection status. Interestingly, volunteers [...] protection since no difference was observed between CHMI protected and non-protected volunteers. Manuscript 5: HIV-1 positive and HIV-1 negative Tanzanian adults undergoing whole irradiation attenuated Plasmodium [...] vaccination mount antibody responses targeting the...