Comparative genomics of <em>Mycobacterium africanum</em> lineage 5 and lineage 6 from Ghana suggests distinct ecological niches (Publications)
Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under [...] epitopes overall compared to L5. Of the 10% human T cell epitopes that were variable, most carried mutations that were lineage-specific. Our findings indicate that Maf L5 and L6 differ in some of their
Spatial PM2.5, NO2, O3 and BC models for Western Europe - evaluation of spatiotemporal stability (Publications)
health relevant air pollutants (PM2.5, NO2, BC, O3) across Europe. METHODS: We developed West-European land use regression models (LUR) for 2010 estimating annual mean PM2.5, NO2, BC and O3 concentrations [...] time, separate models were developed for different years (NO2 and O3: 2000 and 2005; PM2.5: 2013). RESULTS: The PM2.5, BC, NO2, O3 annual, O3 warm season and O3 cold season models explained respectively 72% [...] and 16% of the R(2) in the PM2.5, O3 warm and O3 cold models. Explained...
Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study (Publications)
BACKGROUND: To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering parenteral antimalarials may be difficult. A
Mortality and morbidity effects of long-term exposure to low-level PM2.5, BC, NO2, and O3: an analysis of European cohorts in the ELAPSE project (Publications)
= 1.11, 1.16) for an increase of 5 mug/m(3) PM2.5, 1.09 (CI = 1.07, 1.10) for an increase of 10 mug/m(3) NO2, and 1.08 (CI = 1.06, 1.10) for an increase of 0.5 x 10(-5)/m BC for natural-cause mortality [...] = 1.02, 1.09) for an increase of 5 mug/m(3) PM2.5, 1.04 (CI = 1.02, 1.07) for an increase of 10 mug/m(3) NO2, and 1.04 (CI = 1.02, 1.06) for an increase of 0.5 x 10(-5)/m BC, and 0.95 (CI = 0.93, 0.98) [...] investigate whether the associations persisted below specific concentration values....
Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic... (Publications)
facility workers), with caregivers of children < 5 years of age during three household surveys (N = 9332 caregivers), and with caregivers of children < 5 years of age who were treated with RAS and enrolled
Genome-wide analyses identify <em>SCN5A</em> as a susceptibility locus for premature atrial contraction frequency (Publications)
European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard [...] there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 x 10(-5)). However, several AF risk loci, including PITX2, were not associated with PAC frequency. These
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by
Age and cancer incidence in 5.2 million people with HIV: the South African HIV Cancer Match study (Publications)
Using natural splines, we modelled cancer incidence rates as a function of age. RESULTS: We included 5,222,827 PWH with 29,580 incident cancer diagnoses - most commonly cervical cancer (n = 7418), Kaposi