Acute-phase proteins and mortality in status epilepticus: a 5-year observational cohort study (Publications)
OBJECTIVE: Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown d
Antileukemic ancistrobenomine B and related 5,1′-coupled naphthylisoquinoline alkaloids from the Chinese liana <em>Ancistrocladus tectorius</em> (Publications)
predominance of 5,1'-coupled naphthylisoquinoline alkaloids. About 20 alkaloids of this coupling type have so far been discovered in this plant species. Here, we report on the isolation of four new 5,1'-linked [...] naphthylisoquinolines from the twigs and stems of A. tectorius. Two of them, the ancistrobenomines B (5) and C (6), belong to the very rare group of alkaloids with a fully dehydrogenated isoquinoline portion [...] from one single naphthalene-devoid 3-hydroxymethyleneisoquinoline from...
Incidence of cough from acute exposure to fine particulate matter (PM2.5) in Madagascar: a pilot study (Publications)
association between hourly PM2.5 exposure and cough counts. Peaks in both PM2.5 concentration and cough frequency were observed during the day. A 10-fold increase in hourly PM2.5 concentration corresponded [...] feasibility of objective PM2.5 and cough monitoring in remote settings. An association between hourly PM2.5 exposure and cough frequency was detected, suggesting that PM2.5 exposure may have immediate effects [...] exposure to fine particulate matter (PM2.5) is a known risk to...
<em>TOLLIP</em> and <em>MUC5B</em> modulate the effect of ambient NO2 on respiratory symptoms in infancy (Publications)
Significant interaction was observed between modelled air pollution (weekly NO(2) exposure) and 5 SNPs within MUC5B and TOLLIP genes regarding respiratory symptoms as outcome: E.g., infants carrying minor alleles [...] BACKGROUND: Current knowledge suggests that the gene region containing MUC5B and TOLLIP plays a role in airway defence and airway inflammation, and hence respiratory disease. It is also known that exposure [...] on the immune response and respiratory symptoms in infants may be...
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β (PI4K), identified 1,5-naphthyridines with basic groups
Hourly land-use regression modeling for NO2 and PM2.5 in the Netherlands (Publications)
performed overall well (5-fold cross validation R(2) = 0.50 - 0.78), while the PM(2.5) performed moderately (5-fold cross validation R(2) = 0.24 - 0.62). Both for NO(2) and PM(2.5) the warm season models [...] this study we aimed to model average hourly concentrations for two major pollutants, NO(2) and PM(2.5), for the Netherlands using the LUR algorithm. We modelled the spatial variation of average hourly [...] models performed overall worse than both modelling approaches (NO(2) hourly R(2) =...