A multiplex qPCR approach for detection of <em>pfhrp2 </em>and <em>pfhrp3</em> gene deletions in multiple strain infections of <em>Plasmodium... (Publications)
pfhrp2 and pfhrp3 deletion status correctly in 93.4% of samples with parasitemia levels higher than 5 parasites/µL when compared to nested PCR. The qHRP2/3-del assay can correctly identify pfhrp2 and pfhrp3
Characterization of moxidectin against <em>Strongyloides ratti:</em> <em>in vitro</em> and<em> in vivo </em>activity and pharmacokinetics in the rat... (Publications)
of 250, 500, and 750 mug/kg of moxidectin resulted in a reduction of the worm burden ranging from 48.5 to 75%. At the highest dose (750 mug/kg) we observed a maximal blood concentration of 50.3 ng/mL and
Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a (Publications)
X-ray structural data to inform optimization and then applied a scaffold-hop strategy to identify the 5-carboxamide thiazole hydrazone scaffold (43) with potent sBCL-2 activity (IC(50) 30 nM). Human BCL-XL
Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India (Publications)
estimated to range between 0 and 9 y. Highly endemic settings where control efforts have been ongoing for 5-8 y are most affected by an interruption, for which we identified a mitigation strategy to be most relevant
Gendered determinants of food insecurity in ongoing regional conflicts, North and South Kivu, the Democratic Republic of Congo (Publications)
food insecurity. Results The poorest households were five times more likely to be food insecure (OR = 5.66, 95% CI 3.74–8.55). Women’s participation in decision-making about resource allocation decreased
Five insights from the Global Burden of Disease Study 2019 (Publications)
trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and
The Corona Immunitas Digital Follow-Up eCohort to monitor impacts of the SARS-CoV-2 pandemic in Switzerland: study protocol and first results (Publications)
use, vaccination and vaccine hesitancy, and socio-economic changes. Results: We report data from the 5 centres that enrolled in the CI-DFU between June and October 2020 (covering Basel City/Land, Fribourg
Newcastle-Krankheit: seroepidemiologische Untersuchung einer hochansteckenden Tierseuche beim Geflügel und bei Wildvögeln in der Schweiz (Publications)
NDV-seropositive, and the true NDV seroprevalence in this population was most likely between 1.3 and 1.5%. NDV antibodies were also detected in five of the 169 backyard poultry-flocks. ND-antibody positive
The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated <em>Plasmodium... (Publications)
cure rates were similar, by Day 28 45% of children treated with AQ demonstrated R1 resistance and 27.5% were clinical failures compared with 25% and 6.3%, respectively, for SP alone. Coadministered AQ+SP
Cross-sectional but not prospective association of accelerometry-derived physical activity with quality of life in children and adolescents (Publications)
functioning at school (p = 0.039 and 0.013 respectively). Baseline MVPA was not associated with QoL 5 years later. Conclusion: Future longitudinal studies should employ shorter follow-up times and repeat