European Community Respiratory Health Survey II : final report of work package 6 : PM2.5 assessment in 21 European cities of ECRHS II (Publications)
of the centres varies if PM2.5 mass concentrations are considered season by season and examines the association of NO2 with PM2.5 in the participating centres. Since PM2.5 is not routinely monitored in [...] present the annual mean PM2.5 mass concentrations in the participating centres and to describe the methodology and the European-wide quality control programme for the collection of PM2.5 in the ECRHS II. Furthermore [...] in Europe, we measured PM2.5 mass concentrations in 21 participating...
Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data (Publications)
estimates of PM2.5 and NO2 are increasingly used in combination with Land Use Regression (LUR) models. We aimed to compare the contribution of SAT and CTM data to the performance of LUR PM2.5 and NO2 models [...] monitoring data sets: PM2.5 and NO2 ground level measurements from the European Study of Cohorts for Air Pollution Effects (ESCAPE) and from the European AIRBASE network. LUR PM2.5 models including SAT and [...] and SAT+CTM explained ~60% of spatial variation in measured PM2.5...
Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria... (Publications)
representative survey conducted to provide estimates of malaria prevalence among children less than 5 years, and to track the progress of control interventions in the country. In this present study, 2014-15 [...] were analysed to assess intervention effects on malaria prevalence in Uganda among children less than 5 years, assess intervention effects at regional level, and estimate geographical distribution of malaria [...] status and higher level of mother's education. The highest prevalence of...
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis... (Publications)
FINDINGS: Globally, 5.8 million (95% uncertainty interval [UI] 5.7-6.0) children younger than 5 years died in 2015, representing a 52.0% (95% UI 50.7-53.3) decrease in the number of under-5 deaths since 1990 [...] under-5 mortality. Third, we analysed levels and cause compositions of under-5 mortality, across time and geographies, as they related to rising SDI. Finally, we decomposed the changes in under-5 mortality [...] under-5 mortality, as well as differences in observed and expected rates...
Feasibility, acceptability and clinical utility of the cultural formulation interview: mixed-methods results from the DSM-5 international field trial (Publications)
diagnostic assessment. AIMS: To assess the feasibility, acceptability and clinical utility of the DSM-5 Cultural Formulation Interview (CFI) in routine clinical practice. METHOD: Mixed-methods evaluation [...] significantly and subsequent interviews required less time. CONCLUSIONS: The CFI was included in DSM-5 as a feasible, acceptable and useful cultural assessment tool.
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction (Publications)
includes AGPHD1, IREB2, and CHRNA5/CHRNA3 genes. The region was also modestly associated among never smokers. Gene expression studies confirmed the presence of CHRNA5/3 in lung, airway smooth muscle, and [...] replicated in the COPD meta-analysis. CONCLUSIONS: These results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate
Single-dose hepatitis A immunization: 7.5-year observational pilot study in Nicaraguan children to assess protective effectiveness and humoral immune... (Publications)
virosomal HAV vaccine in 2005, followed by yearly serological and clinical assessments until 2012. After 7.5 years, a vaccine booster was administered. Concurrent antibody screening of patients presenting with
The first population structure and comparative genomics analysis of <em>Mycobacterium africanum</em> strains from Ghana reveals higher diversity of... (Publications)
within a single cluster of L5 strains from Southern Ghana isolated in 2013. Among the global collection of MTB complex, there were four Ghana-specific L5 clusters of which one (L5.1.1) had traits of clonal [...] and 93 L5) of the genomes were de novo assembled and annotated for comparative pangenome analysis using Roary. RESULTS: The population structure of MAF revealed at least five clusters of L5 as compared [...] using whole genome sequencing. METHODS: Clinical MTB complex strains (n=187)...
Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among... (Publications)
Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income). [...] Cost-Effectiveness poLicy (MCMARCEL) was developed to follow RSV-related events monthly from birth until 5 years of age. MCMARCEL was parameterised using country- and age-specific demographic, epidemiological