Epidemiology of paediatric meningitis in central Côte d'Ivoire after the implementation of <em>Haemophilus influenzae</em> type B vaccination (Publications)
with the most prevalent pathogens being Streptococcus pneumoniae (n=15) and Neisseria meningitidis (n=5). With the exception of neonates, these two bacteria were the most common agents in all age groups.
Cross-sectional but not prospective association of accelerometry-derived physical activity with quality of life in children and adolescents (Publications)
functioning at school (p = 0.039 and 0.013 respectively). Baseline MVPA was not associated with QoL 5 years later. Conclusion: Future longitudinal studies should employ shorter follow-up times and repeat
Adoption of Levo-Praziquantel 150mg for schistosomiasis by endemic countries (ADOPT) (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/adoption-of-levo-praziquantel-150mg-for-schistosomiasis-by-endemic-countries-adopt
distribution of praziquantel tablets to school-aged children and at-risk populations. Preschool-aged (≤5 years) children (PSAC) represent another important at-risk group but treatment options for the estimated
Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a (Publications)
X-ray structural data to inform optimization and then applied a scaffold-hop strategy to identify the 5-carboxamide thiazole hydrazone scaffold (43) with potent sBCL-2 activity (IC(50) 30 nM). Human BCL-XL
Building community health resilience and alleviating poverty through multi-sectoral cooperation for elimination of schistosomiasis in Cambodia and Lao... (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/building-community-health-resilience-and-alleviating-poverty-through-multi-sectoral-cooperation-for-elimination-of-schistosomiasis-in-cambodia-and-lao-peoples-democratic-republic
and operational research are designed to measure impacts and generate evidence of success; and target 5: All activities under the Project are implemented according to the proposal. Key activities proposed
Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India (Publications)
estimated to range between 0 and 9 y. Highly endemic settings where control efforts have been ongoing for 5-8 y are most affected by an interruption, for which we identified a mitigation strategy to be most relevant
Influence of <em>M. tuberculosis</em> lineage variability within a clinical trial for pulmonary tuberculosis (Publications)
belonged to the Euro-American lineage, with sublineage 724 predominating at African sites (99/192, 51.5%), and the Euro-American strains other than 724 predominating at non-African sites (89/114, 78.1%).
The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated <em>Plasmodium... (Publications)
cure rates were similar, by Day 28 45% of children treated with AQ demonstrated R1 resistance and 27.5% were clinical failures compared with 25% and 6.3%, respectively, for SP alone. Coadministered AQ+SP
Planning a family: priorities and concerns in rural Tanzania (Publications)
fertility survey using qualitative and quantitative techniques described a high fertility setting (TFR 5.8) in southern Tanzania where family planning use was 16%. Current use was influenced by rising parity
Isolation and propagation of <em>Trypanosoma brucei gambiense </em>from sleeping sickness patients in South Sudan (Publications)
breeds were susceptible after the second subpassage and developed a parasitaemia > 10(6)/ml by Day 5 post infection. The highest parasitaemias were achieved in C57/BL and BALB/c mice. These results indicate