Inhibition of <em>Plasmodium falciparum</em> fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids (Publications)
microM), the more complex flavonoids (12-16) exhibited strong activity toward all three enzymes (IC50 0.5-8 microM). Isoflavonoids 26-28 showed moderate (IC50 7-30 microM) but selective activity against FabZ
Malaria-anemia comorbidity prevalence as a measure of malaria-related deaths in sub-Saharan Africa (Publications)
geostatistical models. Mortality hazard obtained from malaria-anemia comorbidity prevalence was up to 3·5 times higher compared to the hazard related to Plasmodium parasitaemia only. Malaria parasite prevalence
Hunting bats for human consumption in Bangladesh (Publications)
sell live bats to traditional healers. They report that the bat population has declined compared with 5 or 10 years ago, a decline they attribute to hunting and deforestation. Many have heard of a disease
Gendered determinants of food insecurity in ongoing regional conflicts, North and South Kivu, the Democratic Republic of Congo (Publications)
food insecurity. Results The poorest households were five times more likely to be food insecure (OR = 5.66, 95% CI 3.74–8.55). Women’s participation in decision-making about resource allocation decreased
The Corona Immunitas Digital Follow-Up eCohort to monitor impacts of the SARS-CoV-2 pandemic in Switzerland: study protocol and first results (Publications)
use, vaccination and vaccine hesitancy, and socio-economic changes. Results: We report data from the 5 centres that enrolled in the CI-DFU between June and October 2020 (covering Basel City/Land, Fribourg
Artificial light at night influences clock-gene expression, activity, and fecundity in the mosquito <em>Culex pipiens </em>f.<em> Molestus</em> (Publications)
Populations were kept under 16hours (h):8h light:dark cycles or were subjected to an additional 3.5 h of light (100–300 lx) in the evenings. ALAN induced significant changes in expression in all genes
Concurrently measured concentrations of atmospheric mercury in indoor (household) and outdoor air of Basel, Switzerland (Publications)
Basel, Switzerland. Average Hg concentrations ranged from 2.0 to 10.8 ng m–3 indoors and from 1.8 to 2.5 ng m–3 outdoors. These results reveal that households are a net source of Hg to the urban atmosphere
The influence of malaria control interventions and climate variability on changes in the geographical distribution of parasite prevalence in Kenya... (Publications)
indicators and climatic/environmental predictors of parasitaemia risk by age groups (6-59 months and 5-14 years). Parasitaemia risk and the number of infected children were predicted over a 1 × 1 km(2) grid
Adoption of Levo-Praziquantel 150mg for schistosomiasis by endemic countries (ADOPT) (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/adoption-of-levo-praziquantel-150mg-for-schistosomiasis-by-endemic-countries-adopt
distribution of praziquantel tablets to school-aged children and at-risk populations. Preschool-aged (≤5 years) children (PSAC) represent another important at-risk group but treatment options for the estimated
<em>Leptospira</em> seroprevalence among Ugandan slaughter cattle: comparison of sero-status with renal <em>Leptospira </em>infection (Publications)
serovars Tarassovi (sg Tarassovi) (11.6%), Sejroe (Sg Sejroe) (7.8%), and Australis (Sg Australis) (5.2%). Older animals had 2.8 times (95% CI 1.0-8.2, p-value 0.055) greater odds of being seropositive