Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
Both permethrin and deltamethrin were metabolized. Rates were enhanced by A. gambiae cytochrome b(5) with kinetic parameters of K(M)=12+/-4muM and k(cat)=6+/-1 per min for permethrin (1:1 cis-trans) and
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of <em>Scrophularia lepidota</em> roots (Publications)
(2), aucubin (3), 6-O-alpha-L-rhamnopyranosyl-aucubin (sinuatol, 4), 6-O-beta-D-xylopyranosylaucubin (5), ajugol (6), ajugoside (7), an iridoid-related aglycone (10) and angoroside C (11). Nine isolates were
Extremely low frequency magnetic field measurements in buildings with transformer stations in Switzerland (Publications)
39 apartments in 18 buildings. In each room of the apartments ELF-MF was concurrently measured with 5 to 6 EMDEX II meters for 10min. Measured arithmetic mean ELF-MF was 0.59muT in 8 apartments that were
High prevalence of nonconvulsive and subtle status epilepticus in an ICU of a tertiary care center: a three-year observational cohort study (Publications)
rate was 17%. Age over 70 years had independent positive influence on status epilepticus course (OR: 5.135; p=0.0029). Hospital stay increased by 1.13h with each additional hour of status epilepticus (p=0
Insecticide resistance and its association with target-site mutations in natural populations of <em>Anopheles gambiae</em> from eastern Uganda (Publications)
Survival rates to DDT were as high as 85.4%, alongside significant resistance levels to permethrin (38.5%), reduced susceptibility to deltamethrin, but full susceptibility to bendiocarb and malathion. Using
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
cells, and murine peritoneal macrophages were measured, and selectivity indices of 7.8, 62, and 9.5 were determined. This is the first report of a plant natural product with potent IN VIVO activity against
Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: <em>in vivo</em> studies (Publications)
13 compounds demonstrated significant antichagasic activity when administered intraperitoneally for 5-10 days at relatively small doses. The best in vivo activity was demonstrated by amides and sulfonamide
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
exceptionally high level of in vitro activity. Four representative compounds of this type, goyazensolide, 4,5-dihydro-2' ,3' -epoxy-15-deoxygoyazensolide, budlein A and 4,15-isoatriplicolide tiglate, were therefore
Search for antiprotozoal activity in herbal medicinal preparations; new natural leads against neglected tropical diseases (Publications)
ns of Salvia, Valeriana, Hypericum, Silybum, Arnica, and Curcuma exhibited high activity (IC50 < 2.5 microg/mL). They were analytically characterized by UHPLC/ESI-QqTOF-MSMS and the activity-guided fr
Synthesis and <em>in vitro</em> testing of antimalarial activity of non-natural-type neocryptolepines: structure-activity relationship study of 2,11-... (Publications)
synthesis and in vitro anti-malarial evaluations of certain C2 or C8 and C11-disubstituted 6-methyl-5H-indolo[2,3-b]quinoline (neocryptolepine congener) derivatives. To attain higher activities, the st