In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative... (Publications)
the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibition increases the risk [...] against complement components other than C3 and C5 may carry a reduced risk of infection, we compared the effect of inhibitors targeting the terminal pathway (C5), the central complement component C3, the [...] H-binding protein (fHbp). SBA triggered by these cell surface...
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 inflammasome (Publications)
conditions. To uncover the possible therapy for PM(2.5) related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM(2.5) induced lung injury in mice by utilizing the survival [...] findings strongly indicated Sal as an effective precaution against PM(2.5) induced lung injury. Pre-administration of Sal before PM(2.5) treatment reduced the mortality within 120 h and alleviated inflammatory [...] PM(2.5) treatment via regulating Bax/Bcl-2/caspase-3 and...
Hourly land-use regression modeling for NO2 and PM2.5 in the Netherlands (Publications)
performed overall well (5-fold cross validation R(2) = 0.50 - 0.78), while the PM(2.5) performed moderately (5-fold cross validation R(2) = 0.24 - 0.62). Both for NO(2) and PM(2.5) the warm season models [...] this study we aimed to model average hourly concentrations for two major pollutants, NO(2) and PM(2.5), for the Netherlands using the LUR algorithm. We modelled the spatial variation of average hourly [...] models performed overall worse than both modelling approaches (NO(2) hourly R(2) =...
Association between concurrence of multiple risk factors and under-5 mortality: a pooled analysis of data from demographic and health survey in 61... (Publications)
al strategies to address preventable under-5 mortality (U5M). This study aims to assess the associations between concurrence of multiple risk factors and U5M in LMICs. METHODS: We extracted data from the [...] 61 LMICs. Our primary outcome was U5M, defined as deaths from birth to 59 months. Binary logistic regression model was applied to ascertain the association between U5M and a total of 20 critical risk factors [...] factors in each individual and assessed their combined effects on U5M with...
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β (PI4K), identified 1,5-naphthyridines with basic groups
Test-treat-track-test-treat (5T) approach for <em>Schistosoma haematobium</em> elimination on Pemba Island, Tanzania (Publications)
survey was 1.4% (21/1560) in 2021 and 1.5% (24/1645) in 2022. In the household-based survey, it was 3.3% (98/2975) in 2021 and 5.4% (159/2920) in 2022. During the 5T interventions, the microhaematuria prevalence [...] school-based survey in 15 low-prevalence implementation units was 0.5% (7/1560) in 2021 and 0.4% (6/1645) in 2022. In the household-based survey, 0.5% (14/2975) and 0.7% (19/2920) of participants were infected [...] n are needed. We report results, strengths, and shortcomings of...
Incidence of cough from acute exposure to fine particulate matter (PM2.5) in Madagascar: a pilot study (Publications)
association between hourly PM2.5 exposure and cough counts. Peaks in both PM2.5 concentration and cough frequency were observed during the day. A 10-fold increase in hourly PM2.5 concentration corresponded [...] feasibility of objective PM2.5 and cough monitoring in remote settings. An association between hourly PM2.5 exposure and cough frequency was detected, suggesting that PM2.5 exposure may have immediate effects [...] exposure to fine particulate matter (PM2.5) is a known risk to...
<em>TOLLIP</em> and <em>MUC5B</em> modulate the effect of ambient NO2 on respiratory symptoms in infancy (Publications)
Significant interaction was observed between modelled air pollution (weekly NO(2) exposure) and 5 SNPs within MUC5B and TOLLIP genes regarding respiratory symptoms as outcome: E.g., infants carrying minor alleles [...] BACKGROUND: Current knowledge suggests that the gene region containing MUC5B and TOLLIP plays a role in airway defence and airway inflammation, and hence respiratory disease. It is also known that exposure [...] on the immune response and respiratory symptoms in infants may be...
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for... (Publications)
deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age [...] For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; [...] distribution methods for adults and from consideration of survey and...