MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA) (Publications)
(MMP-1) 2G (rs1799750) or the MMP-3 6A (rs3025058) allele but not in homozygous carriers of the 1G or 5A allele. Thus, skin and lung aging are linked in carriers of the 2G or 6A allele. These alleles appear
Drug resistance-conferring mutations in <em>Mycobacterium tuberculosis</em> from Madang, Papua New Guinea (Publications)
region. RESULTS: Phenotypic drug susceptibility tests showed 15.7% resistance to at least one drug and 5.2% multidrug resistant (MDR) TB. Rifampicin resistant strains had the rpoB mutations D516F, D516Y or
Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment (Publications)
for linear trend). Unexpected high new infection rates were observed early in follow-up on days 7 [5/26 (19.2%)] and 14 [24/51 (47.1%)]. These results impact significantly on resistance monitoring and
Prominence of symptoms and level of stigma among depressed patients in Calcutta (Publications)
Calcutta, and met Diagnostic and Statistical Manual (DSM)-IV criteria for a major depressive episode. Only 5 patients (17.2%) identified sadness as the most troubling problem, and 48.3% specified pains and other
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
(95% confidence intervals: 0.1-0.3%) in both rounds compared to a PCR positivity (all species) of 2.5% (2.1-2.9%) and 3.8% (3.2-4.4%) in rounds 1 and 2, respectively. Two fifths (40%) of infections detected
Diagnosis, treatment and risk factors of <em>Strongyloides stercoralis</em> in schoolchildren in Cambodia (Publications)
technique was 88.4% and 75.0%, respectively and their negative predictive values were 96.4% and 92.5%, respectively. The cumulative prevalence of S. stercoralis increased from 18.6% to 24.4%, after analyzing
<em>Strongyloides ratti</em>: in vitro and in vivo activity of tribendimidine (Publications)
of the larval and adult worm burden. For comparison, we also administered ivermectin at a single 0.5 mg/kg oral dose to rats infected with adult S. ratti and found a 90% reduction of larvae and a 100%
Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation (Publications)
albeit with pronounced cytotoxicity. One dimer showed a MIC(99) value against M. tuberculosis of 2.5mug/ml. The alkylated eudistomin N and O derivatives displayed activities down to 18nM against P. falciparum
Prevalence of cardiovascular risk factors in the Basel city population 1989-1990 (Publications)
Hg) is observed in 17% of the men and 12% of the women, whereas an elevated cholesterol level (over 6.5 mmol/l) concerns respectively 39% and 28% of them. Regular cigarette smokers represent 30% of the males
Effect of agricultural activities on prevalence rates, and clinical and presumptive malaria episodes in central Côte d'Ivoire (Publications)
significant difference between the proportions of severe malaria episodes (i.e. axillary temperature> 37.5 degrees C plus parasitaemia> 5000 parasites/mul blood). Our study underscores the complex relationship