Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-<em>O</em>-Methlylamidoxime (Pafuramidine, DB289) against <em>Trypanosoma... (Publications)
consecutive days. The animals in groups 4 and 5 were treated with 10 mg/kg for 10 consecutive days starting on the 14th day p.i. (group 4) or on the 28th day p.i. (group 5), when these animals were in the late [...] of three (group 5) monkeys. These studies demonstrated that pafuramidine was orally active in monkeys with early-stage T. brucei rhodesiense infections at dose rates above 3 mg/kg for 5 days. It was also [...] treatment with parenterally administered medicines. The efficacy of a...
Validation of a questionnaire to assess dietary habits among 5-13-year old school children of farmers and anthroposophic families (Publications)
Objective. To evaluate dietary habits among 5-13-year old school children of farmers, anthroposophic families and controls and to evaluate the validity of a food questionnaire as part of a lifestyle q
Genomic distribution and functional characterisation of two distinct and conserved <em>Plasmodium falciparum</em> var gene 5' flanking sequences (Publications)
conserved types of 5' upstream regions (var17-type and 5B1-type) of var genes, and suggest that most subtelomeric var genes are flanked by a var17-type 5' upstream sequence. In contrast, 5B1-type 5' upstream are [...] that var genes flanked by either type of 5' upstream sequence are transcribed in in vitro cultured trophozoite stage parasites. In addition, we have shown that the 5' flanking sequences of four different
Levels of physical activity and sedentary time among 10- to 12-year-old boys and girls across 5 European countries using accelerometers: an... (Publications)
ABSTRACT: BACKGROUND: The study aim was to objectively assess levels of sedentary time, light, moderate and vigorous physical activity (PA) among 10-12 year olds across five European countries and to
Source apportionment of ambient PM2.5 at five spanish centres of the european community respiratory health survey (ECRHS II) (Publications)
clearly observed in PM2.5. Multi-linear regression analysis (MLRA) was applied to the data, showing that traffic was the main source of PM2.5 at the five sites (39-53% of PM2.5, 5.1-12.0 mgm [...] particulate matter (PM2.5) was sampled at 5 Spanish locations during the European Community Respiratory Health Survey II (ECRHS II). In an attempt to identify and quantify PM2.5 sources, source contribution [...] analysis (PCA) was performed on five datasets containing elemental composition of PM2.5...
Source apportionment of PM2.5 and selected hazardous air pollutants in Seattle (Publications)
with the PM(2.5) data, the models identified that wood burning (24%-31%), secondary sulfate (20%-24%) and secondary nitrate (15%-20%) were the main contributors to PM(2.5). Using only PM(2.5) data, the model [...] of combining the speciated PM(2.5) and VOCs data in source apportionment analysis for identification of additional sources remain unclear. We analyzed the speciated PM(2.5) and VOCs data collected at the [...] constraint. When both PM(2.5) and VOCs data were used, one additional...
Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children (Publications)
C-reactive protein (hsCRP) at the age of 4.5 years. Methods: The high-sensitivity CRP values (n = 653) and serum-specific IgE concentrations were measured from 4.5-year-old children in rural areas in five [...] (aOR 2.51 95% CI 1.12-5.59). Conclusion: We found few associations between early environmental farming factors and hsCRP levels, and between hsCRP levels and atopic sensitization in 4.5-year-old children. [...] Group. Few associations between high-sensitivity C-reactive protein and...
Oxidative properties of ambient PM2.5 and elemental composition: Heterogeneous associations in 19 European cities (Publications)
extent to which constituents of PM2.5 (transition metals, sodium, chloride) contribute to the ability to generate hydroxyl radicals ((OH)-O-center dot) in vitro in PM2.5 sampled at 20 locations in 19 European [...] European centres participating in the European Community Respiratory Health Survey. PM2.5 samples (n = 716) were collected on filters over one year and the oxidative activity of particle suspensions obtained