Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5 (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/preclinical-profiling-of-virosomally-formulated-b-cell-epitope-mimetics-derived-from-the-novel-key-malaria-vaccine-candidates-cyrpa-and-rh5
Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final mult
O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis (Publications)
microscopy, O-150 qPCR, and the novel O-5S qPCR. RESULTS: Among the 200 individuals, 133 patients tested positive (positivity rate of 66.5%) and 67 negative by O-5S qPCR, 74 tested positive by microscopy [...] individuals who tested negative by O-5S qPCR tested positive by microscopy or O-150 qPCR, implying 100% specificity of the newly designed O-5S qPCR assay. CONCLUSIONS: The novel O-5S qPCR assay is more sensitive [...] qPCR (39.0%). Among the 133 O-5S qPCR positive individuals, microscopy...
Feasibility of caregiver-administered anthropometric measurements of children under age 5: evidence from Zambia (Publications)
feasibility and reliability of caregiver-administered anthropometric assessments of children under age 5. DESIGN: We compared standard and caregiver-administered assessments within an ongoing nutrition trial
NETCELL Phase 5 - Core support to the National Malaria Control Programme in Tanzania (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/netcell-phase-5-core-support-to-the-national-malaria-control-programme-in-tanzania
is a clear recognition of the organisational and human resource gaps at the NMCP. The proposed Phase 5 of NETCELL will carry forward these changes and focus on achieving three outcomes: The ITN Cell and [...] mentoring component in order to ensure sustainability of the efforts and continuity of results. This Phase 5 of five years will tackle an enlarged scope of support, while at the same time deepen its structural
Air pollution mixture complexity and its effect on PM2.5-related mortality: a multicountry time-series study in 264 cities (Publications)
oxidative capacity of PM(2.5) or its composition. CONCLUSIONS: The PMCI represents an efficient and simple predictor of local PM(2.5)-related mortality, providing evidence that PM(2.5) toxicity depends on the [...] particulate matter (PM(2.5)) occurs within a mixture of other pollutant gases that interact and impact its composition and toxicity. To characterize the local toxicity of PM(2.5), it is useful to have an [...] evaluate to which extent it relates to PM(2.5) toxicity. METHODS: The PMCI...
Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French... (Publications)
PM(2.5) and NO(2) concentrations during pregnancy were modeled at residential address using land use regression. We assessed associations using logistic regressions per interquartile range (PM(2.5): 3 μg/m(3); [...] associations for PM(2.5) (1.49 (1.03-2.13), p = 0.03) and NO(2) (1.40 (1.08-1.82), p = 0.01) in the urban stratum. At 12-years, main analyses showed a tendency of associations of PM(2.5) (1.38 (0.98-1.93) [...] was to investigate the associations of pregnancy exposure to outdoor fine...
Single- and two-pollutant concentration-response functions for PM2.5 and NO2 for quantifying mortality burden in health impact assessments (Publications)
in HIAs, focusing on long-term exposure to particulate matter with a diameter less than 2.5 micrometers (PM(2.5)) and nitrogen dioxide (NO(2)) and their associations with all-cause mortality. METHODS: A [...] 053 (95% confidence interval: 1.034-1.071) and 1.035 (1.014-1.057), respectively, for a 5 μg/m(3) increase in PM(2.5). HRs for a 10 μg/m(3) increase in NO(2) were 1.032 (1.014-1.049) and 1.024 (1.000-1.049) [...] coefficient difference between single- and two-pollutant models was 0.017 for...
Exploring RF-EMF levels in Swiss microenvironments: an evaluation of environmental and auto-induced downlink and uplink exposure in the era of 5G (Publications)
Compared to the non-user scenario, exposure levels increased substantially during max DL due to the 5G band at 3.5 GHz with 50% of the median levels between 3.20 and 12.13 mW/m(2), mostly in urban areas. Note [...] to measure environmental, auto-induced downlink (DL), and uplink (UL) RF-EMF exposure in the era of 5G. We present results when applying the protocol in Switzerland. Five study areas with different degrees
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity (Publications)
existing therapies are partially ineffective and cause serious adverse effects. Formation of the PEX14-PEX5 complex is essential for protein import into the parasites' glycosomes. This transport is critical for [...] on of glycosomal enzymes, with fatal consequences for the parasite. Hence, inhibiting the PEX14-PEX5 protein-protein interaction (PPI) is an attractive way to affect multiple metabolic pathways. Herein [...] computational screening and optimization to develop the first line of...