HPLC-based activity profiling for antiprotozoal compounds in <em>Croton gratissimus</em> and <em>Cuscuta hyalina</em> (Publications)
vitro. Quercetin-3,7-dimethylether (6) showed the highest activity against axenic L. donovani (IC50, 4.5 µM; selectivity index [SI], 12.3), P. falciparum (IC50, 7.3 µM; SI, 7.6), and T. b. rhodesiense (IC50
Misdiagnosis of leprosy in Brazil in the period 2003-2017: spatial pattern and associated factors (Publications)
Brazil, 2003 - 2017. Factors associated with misdiagnosis were identified by logistic regression at the 5% significance level. RESULT: A total of 574,181 new leprosy cases were recorded in Brazil, of which
Who is best to test? A systematic review of chlamydia infections in Switzerland (Publications)
8.4-18.9), HIV-positive men who have sex with men (10.9%, 95% CI: 9.2-17.6), and adult offenders (6.5%, 95% CI: 3.2-9.0). Systematic screening was suggested for the first two risk groups and women suffering
Structure-activity relationship studies on the macrolide exotoxin mycolactone of <em>Mycobacterium ulcerans</em> (Publications)
(comprising C12-C20) caused less pronounced changes in cytotoxicity than modifications in the lower C5-O-linked polyunsaturated acyl side chain. A derivative with a truncated lower side chain was unique
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing <em>Plasmodium falciparum</em> parasitaemia... (Publications)
three days, or Maloprim (6.25 mg pyrimethamine + 50 mg dapsone for children under 10 years, and 12.5 mg pyrimethamine + 100 mg dapsone for children 10 or more years old) as a single dose. Children were
Prominence of symptoms and level of stigma among depressed patients in Calcutta (Publications)
Calcutta, and met Diagnostic and Statistical Manual (DSM)-IV criteria for a major depressive episode. Only 5 patients (17.2%) identified sadness as the most troubling problem, and 48.3% specified pains and other
Drug resistance-conferring mutations in <em>Mycobacterium tuberculosis</em> from Madang, Papua New Guinea (Publications)
region. RESULTS: Phenotypic drug susceptibility tests showed 15.7% resistance to at least one drug and 5.2% multidrug resistant (MDR) TB. Rifampicin resistant strains had the rpoB mutations D516F, D516Y or
MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA) (Publications)
(MMP-1) 2G (rs1799750) or the MMP-3 6A (rs3025058) allele but not in homozygous carriers of the 1G or 5A allele. Thus, skin and lung aging are linked in carriers of the 2G or 6A allele. These alleles appear
Progression to active tuberculosis, but not transmission, varies by <em>Mycobacterium tuberculosis</em> lineage in The Gambia (Publications)
sensu stricto, contacts exposed to a Beijing family strain were most likely to progress to disease (5.6%; HR relative to M. africanum, 6.7 [95% CI, 2.0-22]). CONCLUSIONS: M. africanum and M. tuberculosis
Validation of two accelerometers to determine mechanical loading of physical activities in children (Publications)
performance of different tasks of daily physical activity in children. Thirteen children (10.1 (range 5.4-15.7) years, 3 girls) wore two accelerometers (ActiGraph GT3X+ (ACT), GENEA (GEN)) at the hip that