Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis (Publications)
as the sialic acid N-glycolylneuraminic acid (Neu5Gc), might play a significant role. METHODS: Exposure to Neu5Gc was evaluated by quantifying anti-Neu5Gc antibody levels in sera of children enrolled in [...] 4.5 years [n = 700], and 6 years [n = 728]), and we associated them with asthma and wheeze. The effect of Neu5Gc was examined in murine airway inflammation and colitis models, and the role of Neu5Gc in [...] in nonatopic subjects. Exposure to Neu5Gc in mice resulted in reduced airway...
Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts (Publications)
per 5 mug/m(3) PM(2.5), 1.10 (0.97, 1.25) per 0.5 10(-5)m(-1) BC, and 0.99 (0.84, 1.17) per 10 mug/m(3) O(3). CONCLUSIONS: We observed indications of an association between exposure to NO(2), PM(2.5), and [...] l exposure to nitrogen dioxide (NO(2)), fine particles (PM(2.5)), black carbon (BC), ozone (O(3)) and eight elemental components of PM(2.5) (copper, iron, potassium, nickel, sulfur, silicon, vanadium, [...] 0-191.9/C71.0-C71.9, 192.0/C72.2-C72.5. We applied Cox proportional hazards models...
Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts (Publications)
41) per 5 μg/m³ PM(2.5), 1.10 (0.97, 1.25) per 0.5 10(-5)m(-1) BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O(3). CONCLUSIONS: We observed indications of an association between exposure to NO(2), PM(2.5), and [...] l exposure to nitrogen dioxide (NO(2)), fine particles (PM(2.5)), black carbon (BC), ozone (O(3)) and eight elemental components of PM(2.5) (copper, iron, potassium, nickel, sulfur, silicon, vanadium, [...] 0-191.9/C71.0-C71.9, 192.0/C72.2-C72.5. We applied Cox proportional hazards models...
Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts (Publications)
41) per 5 μg/m³ PM(2.5), 1.10 (0.97, 1.25) per 0.5 10(-5)m(-1) BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O(3). CONCLUSIONS: We observed indications of an association between exposure to NO(2), PM(2.5), and [...] l exposure to nitrogen dioxide (NO(2)), fine particles (PM(2.5)), black carbon (BC), ozone (O(3)) and eight elemental components of PM(2.5) (copper, iron, potassium, nickel, sulfur, silicon, vanadium, [...] 0-191.9/C71.0-C71.9, 192.0/C72.2-C72.5. We applied Cox proportional hazards models...
Long-term exposure to air pollution and liver cancer incidence in six European cohorts (Publications)
mug/m(3) ), PM2.5 (1.12, 0.92-1.36 per 5 mug/m(3) ), and BC (1.15, 1.00-1.33 per 0.5 10(-5) /m) and liver cancer incidence. Associations with NO2 and BC persisted in two-pollutant models with PM2.5 . Most components [...] dioxide (NO2 ), particulate matter with diameter < 2.5 mum (PM2.5 ), black carbon (BC), warm-season ozone (O3 ), and eight elemental components of PM2.5 (copper, iron, zinc, sulfur, nickel, vanadium, silicon [...] components of PM2.5 were associated with the risk of liver...
Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects... (Publications)
models for particulate matter (PM) below 10 microm (PM10 ), below 2.5 microm (PM2.5 ), between 2.5 and 10 microm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated [...] effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 (1.30;3.01)) as compared to women (HR 0.85 (0.5;1.45)). This large m [...] cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an...
Sources of fine particulate matter in personal exposures and residential indoor, residential outdoor and workplace microenvironments in the Helsinki... (Publications)
larger contributor to residential and workplace indoor PM2.5 than soil dust to residential outdoor PM2.5. Source contributions to personal PM2.5 exposures were best approximated by data from residential [...] each source type to the total PM2.5 mass concentrations. RESULTS: Inorganic secondary particles, primary combustion, and soil were the dominant source types for the PM2.5 mass concentration in all the m [...] OBJECTIVES: This study assessed the source contributions to the mass...
Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area (Publications)
associated with personal PM(2.5), personal LAC, and E(ag) but not with ambient PM(2.5) or its combustion markers. In contrast, MEF and PEF decrements were associated with ambient PM(2.5), its combustion markers [...] and personal concentrations of PM(2.5) and light-absorbing carbon (LAC). Levoglucosan (LG), a marker of woodsmoke, was also measured outdoors. We partitioned PM(2.5) exposure into its ambient-generated [...] personal PM(2.5) or personal LAC. FEV(1) was associated only with ambient...
Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area (Publications)
associated with personal PM(2.5), personal LAC, and E(ag) but not with ambient PM(2.5) or its combustion markers. In contrast, MEF and PEF decrements were associated with ambient PM(2.5), its combustion markers [...] and personal concentrations of PM(2.5) and light-absorbing carbon (LAC). Levoglucosan (LG), a marker of woodsmoke, was also measured outdoors. We partitioned PM(2.5) exposure into its ambient-generated [...] personal PM(2.5) or personal LAC. FEV(1) was associated only with ambient...
Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects... (Publications)
models for particulate matter (PM) below 10 microm (PM10 ), below 2.5 microm (PM2.5 ), between 2.5 and 10 microm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated [...] effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 (1.30;3.01)) as compared to women (HR 0.85 (0.5;1.45)). This large m [...] cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an...