Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone (Publications)
hamsters and S. japonicum-infected mice. RESULTS: Ro 15-5458 had single-dose ED50 values of 15 and 5.3 mg/kg in mice harbouring juvenile and adult S. mansoni infections, respectively. An ED50 value of
Nifurtimox-eflornithine combination therapy for second-stage <em>Trypanosoma brucei gambiense</em> sleeping sickness: a randomized clinical trial in... (Publications)
nifurtimox-eflornithine group. Drug reactions were frequent in both arms, and severe reactions affected 25.5% of patients in the eflornithine group and 9.6% of those in the nifurtimox-eflornithine group, resulting
No excess risk of adverse birth outcomes in populations living near special waste landfill sites in Scotland (Publications)
(0.27 to 2.23) for abdominal wall defects (1.32 (0.42-4.17) for hospital admissions), 1.22 (0.28 to 5.38) for surgical correction of gastroschisis and exomphalos and 1.01 (0.96 to 1.07) and 1.01 (0.90 to
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
malaria infects approximately 240 million people and causes over 600,000 deaths, mostly in children under 5 years of age. For the past decade, artemisinin-based combination therapies have been recommended by
Evaluation of malaria rapid diagnostic test performance and <em>pfhrp2</em> deletion in Tanzania school surveys, 2017 (Publications)
reference, the sensitivity and specificity of mRDT was 76.2% (95% CI: 74.7-77.7) and 93.9% (95% CI: 93.5-94.3), respectively. Test agreement was lowest in low transmission areas, where true-positive mRDTs
Modeling the persistence of <em>Opisthorchis viverrini</em> worm burden after mass-drug administration and education campaigns with systematic... (Publications)
and education campaigns indirectly, using epidemiological data collected in Lao PDR before and after 5 years of repeated MDA, education and sanitation improvement campaigns. We predict the impact of int
Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia (Publications)
conducted with qualitative and quantitative data analysis. Firstly, 14 in-depth cognitive interviews (5 in Zambia and 9 in Lesotho) were performed to assess the participants' understanding of the instructions
Health system utilization and perceived quality among adults in Lao PDR: evidence from a nationally representative phone survey (Publications)
representative estimates. RESULTS: A total of 2007 adults completed interviews in approximately 3.5 months. About two thirds (65%) of respondents reported visiting a health facility in the past year and
Global and regional cardiovascular mortality attributable to nonoptimal temperatures over time (Publications)
a multivariate meta-regression model was developed between location-specific effect estimates and 5 meta-predictors. Third, cardiovascular deaths associated with nonoptimal, cold, and hot temperatures
DDT contamination in water resources of some African countries and its impact on water quality and human health (Publications)
sampled water sources. The highest DDT concentrations were found in South Africa (81.2 μg/L) and Egypt (5.62 μg/L). DDT residues were detected throughout the year in African water systems, but levels were found