An atypical mitochondrial carrier that mediates drug action in <em>Trypanosoma brucei</em> (Publications)
analyses of parasites over-expressing TbMCP14 showed increased levels of the proline metabolite, pyrroline-5-carboxylate, suggesting a possible involvement of TbMCP14 in energy production. The generation of TbMCP14
Atopic sensitization in the first year of life (Publications)
Allergy-Study in Rural Environments (PASTURE) birth cohort including 793 children from rural regions of 5 European countries. Detailed information on children's health, nutrition, and farm-related exposures
The impact of obesity on mortality in UA/non-ST-segment elevation myocardial infarction (Publications)
revascularization. Patients were divided into four groups according to body mass index (BMI): normal, 18.5-24.9 (n = 551); overweight, 25-29.9 (n = 824); obese, 30-34.9 (n = 244); and very obese, above 35 (n
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone (Publications)
hamsters and S. japonicum-infected mice. RESULTS: Ro 15-5458 had single-dose ED50 values of 15 and 5.3 mg/kg in mice harbouring juvenile and adult S. mansoni infections, respectively. An ED50 value of
Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Côte d'Ivoire: a phase II... (Publications)
arm. Sample size in PSAC was considered too small to derive meaningful conclusions. Only 10.7% and 5.1% of participants reported any adverse event at 3 hours and 24 hours post-treatment, respectively.
Use of disability adjusted life years in the estimation of the disease burden of echinococcosis for a high endemic region of the Tibetan plateau (Publications)
Shiqu County were 4.6% for AE and 4.9% for CE with an estimated overall adjusted prevalence rate of 9.5%. The burden of disease associated with echinococcosis was calculated using disability adjusted life
Low-grade inflammation and estimates of insulin resistance during the menstrual cycle in lean and overweight women (Publications)
determined by the homeostasis model assessment index (42%) than when estimated by SHBG concentrations (5%, P < 0.05). During the menstrual cycle, using repeated measurements, hs-CRP correlated inversely to
Isolation of <em>Trypanosoma brucei gambiense</em> from cured and relapsed sleeping sickness patients and adaptation to laboratory mice (Publications)
a major public health problem in some central African countries. Historically, relapse rates around 5% have been observed for treatment with melarsoprol, widely used to treat second stage patients. Later
Comparative analysis of <em>Mycobacterium tuberculosis</em> <em>pe </em>and <em>ppe</em> genes reveals high sequence variation and an apparent absence... (Publications)
genetic variation. This work has been supplemented by whole gene sequencing of 14 pe/ppe (including 5 pe_pgrs) genes in a cohort of 40 diverse and well defined clinical isolates covering all the main lineages
How much remains undetected? Probability of molecular detection of human <em>Plasmodia</em> in the field (Publications)
infection (MOI). METHODS: Samples were obtained in a repeated cross-sectional field survey in 1 to 4.5 years old children from Papua New Guinea, who were followed up in 2-monthly intervals over 16 months
