Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study to identify novel, small-molecule inhibitors of...
Child survival gains in Tanzania: analysis of data from demographic and health surveys (Publications)
reduction in mortality in children younger than 5 years in Tanzania between 2000 and 2004. In 1990, the point estimate of mortality was 141.5 (95% CI 141.5-141.5) deaths per 1000 livebirths. This was reduced [...] recent national survey in Tanzania reported that mortality in children younger than 5 years dropped by 24% over the 5 years between 2000 and 2004. We aimed to investigate yearly changes to identify what [...] health surveys done in Tanzania since 1990 to generate estimates of mortality...
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study to identify novel, small-molecule inhibitors of...
Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within... (Publications)
092) for exposure lower than 1.5x 10(-5)/m, and 1.081 (0.966-1.210) for exposure lower than 1.0x 10(-5)/m. INTERPRETATION: Long-term exposure to concentrations of PM(2.5) and NO(2) lower than current annual [...] between non-accidental mortality and PM(2.5), NO(2), and black carbon, with a hazard ratio (HR) of 1.053 (95% CI 1.021-1.085) per 5 mug/m(3) increment in PM(2.5), 1.044 (1.019-1.069) per 10 mug/m(3) NO(2) [...] NO(2), and 1.039 (1.018-1.059) per 0.5 x 10(-5)/m black carbon. Associations...
Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within... (Publications)
092) for exposure lower than 1.5x 10(-5)/m, and 1.081 (0.966-1.210) for exposure lower than 1.0x 10(-5)/m. INTERPRETATION: Long-term exposure to concentrations of PM(2.5) and NO(2) lower than current annual [...] between non-accidental mortality and PM(2.5), NO(2), and black carbon, with a hazard ratio (HR) of 1.053 (95% CI 1.021-1.085) per 5 mug/m(3) increment in PM(2.5), 1.044 (1.019-1.069) per 10 mug/m(3) NO(2) [...] NO(2), and 1.039 (1.018-1.059) per 0.5 x 10(-5)/m black carbon. Associations...
Burden of disease in Germany attributed to ambient particulate matter pollution : findings from the Global Burden of Disease Study 2019 (Publications)
INTRODUCTION: Ambient fine particulate matter pollution with a diameter less than 2.5 micrometers (PM(2.5)) is a significant risk factor for chronic noncommunicable diseases (NCDs), leading to a substantial [...] years lived with disability (YLDs), and deaths attributed to ambient PM(2.5) pollution in Germany. RESULTS: In 2019, ambient PM(2.5) pollution in Germany was associated with significant health impacts, c [...] disease burden associated with ambient PM(2.5) pollution in Germany from...
microRNA expression profiles and personal monitoring of exposure to particulate matter (Publications)
hsa-miR-4454, hsa-miR-4763-3p, hsa-miR-425-5p, hsa-let-7d-5p, hsa-miR-502-5p, and hsa-miR-505-3p were significantly (FDR corrected) expressed in association with PM2.5 personal exposure, while no significant [...] present study, we investigated the relationship between particulate matter (PM) smaller than 2.5 mum (PM2.5), PM2.5 absorbance (as a proxy of black carbon and soot), and ultrafine-particles (UFP, smaller than [...] other pollutants. The results obtained from this investigation suggest...
Pyrimidine salvage in <em>Trypanosoma brucei</em> bloodstream forms and the trypanocidal action of halogenated pyrimidines (Publications)
the anticancer drug 5-fluorouracil was an excellent substrate for TbU3 and several 5-fluoropyrimidine analogues were investigated for uptake and trypanocidal activity; 5F-orotic acid, 5F-2'deoxyuridine displayed [...] strains. The analysis showed that 5-fluorouracil is incorporated into a large number of metabolites but likely exerts toxicity through incorporation into RNA. 5F-2'dUrd and 5F-2'dCtd are not incorporated into [...] into nucleic acids but act as prodrugs by inhibiting thymidylate...
Smoking cessation, lung function, and weight gain: a follow-up study (Publications)
3) and -5.1 mL (-7.5 to -2.8), respectively. These sex differences were not significant. FEV1 changed by -11.5 mL (-13.3 to -9.6) per kg weight gained in men, and by -3.7 mL per kg (-5.0 to -2.5) in women [...] difference 5.4 mL per year, 95% CI 1.7 to 9.1) and those who quit between surveys (2.5 mL, -1.9 to 7.0), and greater in smokers (-4.8 mL, -7.9 to -1.6). In women, estimates were 1.3 mL per year (-1.5 to 4.1)
Burden of disease in Germany attributed to ambient particulate matter pollution : findings from the Global Burden of Disease Study 2019 (Publications)
INTRODUCTION: Ambient fine particulate matter pollution with a diameter less than 2.5 micrometers (PM(2.5)) is a significant risk factor for chronic noncommunicable diseases (NCDs), leading to a substantial [...] years lived with disability (YLDs), and deaths attributed to ambient PM(2.5) pollution in Germany. RESULTS: In 2019, ambient PM(2.5) pollution in Germany was associated with significant health impacts, c [...] disease burden associated with ambient PM(2.5) pollution in Germany from...