Synthesis and antiprotozoal activity of aza-analogues of furamidine (Publications)
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a), through the bis-O-acetoxyamidoxime followed by hydrogenation. Compound 4a [...] 4c and 4d, respectively. N-Methoxy-6-[5-[4-(N-methoxyamidino)phenyl]-furan-2-yl]-nicotinamidine (6a) was prepared via methylation of the respective diamidoxime 5a with dimethylsulfate. Prodrugs 6b and [...] and 6c were also prepared by methylation of the respective diamidoximes 5b and 5d. The...
Conférences (Page)
https://www.swisstph.ch/fr/about/events/open-house-2023/lectures
Krankheit Gerd Pluschke SR5 DE 11:30-11:55 Swiss TPH im Fokus Jürg Utzinger SR4 DE 11:30-11:55 Reisegesundheit: Wie funktioniert eine Malaria-Prophylaxe? Andreas Neumayr SR5 DE 12:00-12:25 Wie Parasiten [...] Mäusezahl SR5 DE 13:30-13:55 Blutsauger im Visier: Was gibt es Neues in der Mückenforschung? Pie Müller SR4 DE 13:30-13:55 From Lab to Patient: The Fascinating Journey of Drug Development Elisabeth Reus SR5 EN [...] Knoblauch SR1 DE 14:00-14:25 5G-Antennen: Wie stark werden wir bestrahlt?...
Child survival gains in Tanzania: analysis of data from demographic and health surveys (Publications)
reduction in mortality in children younger than 5 years in Tanzania between 2000 and 2004. In 1990, the point estimate of mortality was 141.5 (95% CI 141.5-141.5) deaths per 1000 livebirths. This was reduced [...] recent national survey in Tanzania reported that mortality in children younger than 5 years dropped by 24% over the 5 years between 2000 and 2004. We aimed to investigate yearly changes to identify what [...] health surveys done in Tanzania since 1990 to generate estimates of mortality...
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study...
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (Publications)
best inhibitors included the compounds 5'-tritylamino-2',5'-dideoxyuridine (2j) (Ki = 0.2 microM) and 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine (5h) (Ki = 1.3 microM), with selectivity greater [...] is described in which the substituents are introduced at the 3'- and 5'-positions, together with variation in the heteroatom at the 5'-position. The compounds were assayed against recombinant Plasmodium [...] a structure-activity study...
Child survival gains in Tanzania: analysis of data from demographic and health surveys (Publications)
reduction in mortality in children younger than 5 years in Tanzania between 2000 and 2004. In 1990, the point estimate of mortality was 141.5 (95% CI 141.5-141.5) deaths per 1000 livebirths. This was reduced [...] recent national survey in Tanzania reported that mortality in children younger than 5 years dropped by 24% over the 5 years between 2000 and 2004. We aimed to investigate yearly changes to identify what [...] health surveys done in Tanzania since 1990 to generate estimates of mortality...
Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within... (Publications)
092) for exposure lower than 1.5x 10(-5)/m, and 1.081 (0.966-1.210) for exposure lower than 1.0x 10(-5)/m. INTERPRETATION: Long-term exposure to concentrations of PM(2.5) and NO(2) lower than current annual [...] between non-accidental mortality and PM(2.5), NO(2), and black carbon, with a hazard ratio (HR) of 1.053 (95% CI 1.021-1.085) per 5 mug/m(3) increment in PM(2.5), 1.044 (1.019-1.069) per 10 mug/m(3) NO(2) [...] NO(2), and 1.039 (1.018-1.059) per 0.5 x 10(-5)/m black carbon. Associations...
Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within... (Publications)
092) for exposure lower than 1.5x 10(-5)/m, and 1.081 (0.966-1.210) for exposure lower than 1.0x 10(-5)/m. INTERPRETATION: Long-term exposure to concentrations of PM(2.5) and NO(2) lower than current annual [...] between non-accidental mortality and PM(2.5), NO(2), and black carbon, with a hazard ratio (HR) of 1.053 (95% CI 1.021-1.085) per 5 mug/m(3) increment in PM(2.5), 1.044 (1.019-1.069) per 10 mug/m(3) NO(2) [...] NO(2), and 1.039 (1.018-1.059) per 0.5 x 10(-5)/m black carbon. Associations...
Burden of disease in Germany attributed to ambient particulate matter pollution : findings from the Global Burden of Disease Study 2019 (Publications)
INTRODUCTION: Ambient fine particulate matter pollution with a diameter less than 2.5 micrometers (PM(2.5)) is a significant risk factor for chronic noncommunicable diseases (NCDs), leading to a substantial [...] years lived with disability (YLDs), and deaths attributed to ambient PM(2.5) pollution in Germany. RESULTS: In 2019, ambient PM(2.5) pollution in Germany was associated with significant health impacts, c [...] disease burden associated with ambient PM(2.5) pollution in Germany from...
microRNA expression profiles and personal monitoring of exposure to particulate matter (Publications)
hsa-miR-4454, hsa-miR-4763-3p, hsa-miR-425-5p, hsa-let-7d-5p, hsa-miR-502-5p, and hsa-miR-505-3p were significantly (FDR corrected) expressed in association with PM2.5 personal exposure, while no significant [...] present study, we investigated the relationship between particulate matter (PM) smaller than 2.5 mum (PM2.5), PM2.5 absorbance (as a proxy of black carbon and soot), and ultrafine-particles (UFP, smaller than [...] other pollutants. The results obtained from this investigation suggest...
