Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries (Publications)
and 14.3% (95% CI 14.1-14.5) at low, medium, and high levels of PM2.5, respectively. Similarly, cardiovascular mortality increased by 1.6 (95%CI 1.5-1.6), 5.1 (95%CI 5.1-5.2), and 8.7 (95%CI 8.7-8.8) [...] Location-specific daily death counts and exposure data (e.g., particulate matter with diameters ≤ 2.5 µm [PM2.5]) were obtained from 2000 to 2018. We used location-specific confounder-adjusted Quasi-Poisson [...] pollutant. We extracted heat effects at low, medium, and high levels of...
Reducing ambient levels of fine particulates could substantially improve health: a mortality impact assessment for 26 European cities (Publications)
that could be prevented by reducing PM(2.5) annual levels to 25 microg/m3, 20 microg/m3, 15 microg/m3 and 10 microg/m3 in 26 European cities. The various PM(2.5) concentrations were chosen as different [...] derived from the paper by Pope et al (2002). If no direct PM(2.5 )measurements were available, then the PM(10) measurements were converted to PM(2.5 )using a local or an assumed European conversion factor. We [...] conversion factor for PM(2.5). Specifically, using the "at least" approach,...
Development and evaluation of a personal particulate organic and mass sampler (Publications)
outdoor site, and in residences. Daily particulate mass concentrations averaged 10.0 +/- 5.2, 12.0 +/- 5.3, and 11.2 +/- 5.1 microg m(-3) for the Federal Reference Method, the Harvard Personal Exposure Monitor [...] a series of PM2.5 indoor organic carbon (OC) measurements from single quartz filters, the apparent indoor OC averaged 7.7 +/- 0.8 microg of C m(-3), which was close to the indoor PM2.5 mass from collocated [...] developed to meet these criteria. The PPOMS uses activated...
Configurationally stabilized analogs of <em>M. ulcerans</em> exotoxins mycolactones A and B reveal the importance of side chain geometry for... (Publications)
isomers about the C4' horizontal lineC5' double bond of the C5-side chain. Here, we describe the syntheses of mycolactone analogs with configurationally stable C5-side chains (2a, E mimetic; 2b/c, Z mimetics) [...] mimetics). Based on the cytotoxicity of 2a-c, the Delta(4',5')-trans isomer of mycolactones A/B (1b) appears to be the major virulence factor.
Configurationally stabilized analogs of <em>M. ulcerans</em> exotoxins mycolactones A and B reveal the importance of side chain geometry for... (Publications)
isomers about the C4' horizontal lineC5' double bond of the C5-side chain. Here, we describe the syntheses of mycolactone analogs with configurationally stable C5-side chains (2a, E mimetic; 2b/c, Z mimetics) [...] mimetics). Based on the cytotoxicity of 2a-c, the Delta(4',5')-trans isomer of mycolactones A/B (1b) appears to be the major virulence factor.
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho (Publications)
(95%CI: 61.3-78.0), 67.3% (57.3-76.3) and 74.4% (65.5-82.0), respectively. The respective specificity was 97.9% (97.1-98.4), 97.9% (97.2-98.5) and 97.5% (96.7-98.2). For both sampling modalities, sensitivity [...] had a valid PCR result (61% female, median age 41 years, 8% children), 84.5% were symptomatic. Overall PCR positivity rate was 5.8%. The sensitivity for nasopharyngeal, nasal, and combined nasal and na [...] for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT)....
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho (Publications)
(95%CI: 61.3-78.0), 67.3% (57.3-76.3) and 74.4% (65.5-82.0), respectively. The respective specificity was 97.9% (97.1-98.4), 97.9% (97.2-98.5) and 97.5% (96.7-98.2). For both sampling modalities, sensitivity [...] had a valid PCR result (61% female, median age 41 years, 8% children), 84.5% were symptomatic. Overall PCR positivity rate was 5.8%. The sensitivity for nasopharyngeal, nasal, and combined nasal and na [...] for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT)....
Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project (Publications)
incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur [...] statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 microg/m(3) for 2010 exposure and 1.06 (95% CI: [...] association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00-1.16...
Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project (Publications)
incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur [...] statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 microg/m(3) for 2010 exposure and 1.06 (95% CI: [...] association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00-1.16...
Coarse particulate air pollution and daily mortality: a global study in 205 cities (Publications)
ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale. OBJECTIVES: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and [...] exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10. [...] respiratory) and air pollution data from 205 cities in 20 countries/regions....