Revised EU and WHO air quality thresholds: where does Europe stand? (Publications)
47.5% (36.2, 59.5%) lived in areas where the revised EU thresholds were exceeded. For PM10, the proportion of people exposed to concentrations above the WHO annual thresholds was estimated at 62.5% (54 [...] harmful pollutants, namely PM2.5, PM10, and NO2. The results have shown that in 2021, 97.6% (95% credible interval: 95.1, 99.2%) of the total European population was exposed to PM2.5 levels exceeding the new [...] above the EU values, whereas for NO2, the estimates were at 67.4% (57.9,...
Ambient air pollution and cardiorespiratory outcomes amongst adults residing in four informal settlements in the western province of South Africa (Publications)
Land-Use Regression for Particulate Matter (PM2.5) and Nitrogen Dioxide (NO2) at participants' homes. The median age of the participants was 40.7 years, and 88.5% were female. The median annual NO2 level was [...] annual PM2.5 level was 9.7 microg/m(3) (IQR: 7.3-12.4). Logistic regression analysis was used to assess associations between outcome variables and air pollutants. An interquartile range increase of 5.12 microg/m(3) [...] microg/m(3) in PM2.5 was significantly associated with an...
Revised EU and WHO air quality thresholds: where does Europe stand? (Publications)
47.5% (36.2, 59.5%) lived in areas where the revised EU thresholds were exceeded. For PM10, the proportion of people exposed to concentrations above the WHO annual thresholds was estimated at 62.5% (54 [...] harmful pollutants, namely PM2.5, PM10, and NO2. The results have shown that in 2021, 97.6% (95% credible interval: 95.1, 99.2%) of the total European population was exposed to PM2.5 levels exceeding the new [...] above the EU values, whereas for NO2, the estimates were at 67.4% (57.9,...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from <em>Xanthium... (Publications)
lactones (STL) of the xanthanolide series (4,5-seco-guaianolide-type). They were identified by spectroscopic means as 8-epixanthatin ( 1), 8-epixanthatin 1beta,5beta-epoxide ( 2), and as the dimers pungiolide [...] pungiolide A ( 4) as well as pungiolide B ( 5). Two further modified xanthanolide sesquiterpene lactones, xanthipungolide ( 3) and 4,15-dinor-1,11(13)-xanthadiene-3,5beta:12,8beta-diolide ( 6) were isolated [...] single compound from this extract, 8-epixanthatin 1beta,5beta-epoxide...
Tick species from cattle in the Adama Region of Ethiopia and pathogens detected (Publications)
variegatum (n = 22, 7.5%), Rhipicephalus pulchellus (n = 19, 6.5%), and Rhipicephalus decoloratus (n = 9, 3.0%). Among all ticks, 32 (11%) were positive for Rickettsia spp. and 15 (5.2%) of these were identified [...] variegatum (n = 10) and A. cohaerens (n = 5). The remainder of Rickettsia-positive samples could not be amplified due to low DNA yield. Furthermore, another 15 (5.2%) samples carried other pathogenic bacteria: [...] PCR. Species identification was done by phylogenetic analysis...
Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort (Publications)
confidence interval) of 1.03 (1.00, 1.06) per 10 mug/m(3) NO2, 1.06 (1.01, 1.11) per 5 mug/m(3) PM2.5, 1.03 (0.99, 1.06) per 0.5 10-5m-1 BC, and 0.98 (0.94, 1.01) per 10 mug/m(3) O3. The effect estimates were most [...] in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5 and BC in development of breast cancer. [...] association between long-term residential levels of ambient nitrogen dioxide (NO2),...
Long-term exposure to air pollution and chronic kidney disease-associated mortality - results from the pooled cohort of the European multicentre... (Publications)
Associations were positive for PM(2.5) (hazard ratio (HR) with 95% confidence interval (CI) of 1.31 (1.03-1.66) per 5μg/m(3), BC (1.26 (1.03-1.53) per 0.5×10(- 5)/m), NO(2) (1.13 (0.93-1.38) per 10μg/m(3)) [...] dioxide (NO(2)), black carbon (BC), ozone (O(3)), particulate matter ≤2.5μm (PM(2.5)) and several elemental constituents of PM(2.5). Cox regression models were adjusted for age, sex, cohort, calendar year
Monthly average air pollution models using geographically weighted regression in Europe from 2000 to 2019 (Publications)
structure, particularly for O(3), PM(10), and PM(2.5). The 5-fold CV showed generally good performance of the monthly GWR models across months and years (5-fold CV R(2): 0.31-0.66 for NO(2), 0.4-0.79 for [...] models to estimate monthly concentrations of regulated air pollutants (NO(2), O(3), PM(10) and PM(2.5)) between 2000 and 2019. Monthly average concentrations were collected from routine monitoring stations [...] estimate spatially-varying regression coefficients for each month. Model...
