Health workers' use of malaria rapid diagnostic tests (RDTs) to guide clinical decision making in rural dispensaries, Tanzania (Publications)
all tested individuals were children < 5 years of age. The RDT results were recorded for 10,650 patients (99.2%). Among the 5,488 (51.5%) RDT-positive patients, 5,256 (98.6%) were treated with an appropriate [...] Health workers received training on how to perform RDTs for patients 5 years of age or older with fever or suspected malaria. Children < 5 years of age were to be treated empirically per national guidelines [...] appropriate first-line antimalarial per national guidelines...
Ambient air pollution and cardiorespiratory outcomes amongst adults residing in four informal settlements in the western province of South Africa (Publications)
Land-Use Regression for Particulate Matter (PM2.5) and Nitrogen Dioxide (NO2) at participants' homes. The median age of the participants was 40.7 years, and 88.5% were female. The median annual NO2 level was [...] annual PM2.5 level was 9.7 microg/m(3) (IQR: 7.3-12.4). Logistic regression analysis was used to assess associations between outcome variables and air pollutants. An interquartile range increase of 5.12 microg/m(3) [...] microg/m(3) in PM2.5 was significantly associated with an...
Revised EU and WHO air quality thresholds: where does Europe stand? (Publications)
47.5% (36.2, 59.5%) lived in areas where the revised EU thresholds were exceeded. For PM10, the proportion of people exposed to concentrations above the WHO annual thresholds was estimated at 62.5% (54 [...] harmful pollutants, namely PM2.5, PM10, and NO2. The results have shown that in 2021, 97.6% (95% credible interval: 95.1, 99.2%) of the total European population was exposed to PM2.5 levels exceeding the new [...] above the EU values, whereas for NO2, the estimates were at 67.4% (57.9,...
Revised EU and WHO air quality thresholds: where does Europe stand? (Publications)
47.5% (36.2, 59.5%) lived in areas where the revised EU thresholds were exceeded. For PM10, the proportion of people exposed to concentrations above the WHO annual thresholds was estimated at 62.5% (54 [...] harmful pollutants, namely PM2.5, PM10, and NO2. The results have shown that in 2021, 97.6% (95% credible interval: 95.1, 99.2%) of the total European population was exposed to PM2.5 levels exceeding the new [...] above the EU values, whereas for NO2, the estimates were at 67.4% (57.9,...
Ambient air pollution and cardiorespiratory outcomes amongst adults residing in four informal settlements in the western province of South Africa (Publications)
Land-Use Regression for Particulate Matter (PM2.5) and Nitrogen Dioxide (NO2) at participants' homes. The median age of the participants was 40.7 years, and 88.5% were female. The median annual NO2 level was [...] annual PM2.5 level was 9.7 microg/m(3) (IQR: 7.3-12.4). Logistic regression analysis was used to assess associations between outcome variables and air pollutants. An interquartile range increase of 5.12 microg/m(3) [...] microg/m(3) in PM2.5 was significantly associated with an...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal [...] anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from <em>Xanthium... (Publications)
lactones (STL) of the xanthanolide series (4,5-seco-guaianolide-type). They were identified by spectroscopic means as 8-epixanthatin ( 1), 8-epixanthatin 1beta,5beta-epoxide ( 2), and as the dimers pungiolide [...] pungiolide A ( 4) as well as pungiolide B ( 5). Two further modified xanthanolide sesquiterpene lactones, xanthipungolide ( 3) and 4,15-dinor-1,11(13)-xanthadiene-3,5beta:12,8beta-diolide ( 6) were isolated [...] single compound from this extract, 8-epixanthatin 1beta,5beta-epoxide...
Tick species from cattle in the Adama Region of Ethiopia and pathogens detected (Publications)
variegatum (n = 22, 7.5%), Rhipicephalus pulchellus (n = 19, 6.5%), and Rhipicephalus decoloratus (n = 9, 3.0%). Among all ticks, 32 (11%) were positive for Rickettsia spp. and 15 (5.2%) of these were identified [...] variegatum (n = 10) and A. cohaerens (n = 5). The remainder of Rickettsia-positive samples could not be amplified due to low DNA yield. Furthermore, another 15 (5.2%) samples carried other pathogenic bacteria: [...] PCR. Species identification was done by phylogenetic analysis...
Breast cancer incidence in relation to long-term low-level exposure to air pollution in the ELAPSE pooled cohort (Publications)
confidence interval) of 1.03 (1.00, 1.06) per 10 mug/m(3) NO2, 1.06 (1.01, 1.11) per 5 mug/m(3) PM2.5, 1.03 (0.99, 1.06) per 0.5 10-5m-1 BC, and 0.98 (0.94, 1.01) per 10 mug/m(3) O3. The effect estimates were most [...] in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5 and BC in development of breast cancer. [...] association between long-term residential levels of ambient nitrogen dioxide (NO2),...
