Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese <em>Ancistrocladus</em> liana and their... (Publications)
further new dimeric analogs, michellamines B4 (3) and B5 (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A1 (5) and A2 (6), which, besides one single known other [...] the highest cytotoxic activities, comparable to that of the standard agent, 5-fluorouracil. Furthermore, ancistrobonsolines A1 (5) and A2 (6) showed weak-to-moderate antiprotozoal activities. [...] Michellamines A6 (1) and A7 (2) are the first dimers of 5,8′-coupled naphthylisoquinoline...
Long-term exposure to source-specific fine particles and mortality horizontal line a pooled analysis of 14 European cohorts within the ELAPSE project (Publications)
oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure [...] fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through [...] source apportionment analysis. Exposure to 2010 annual average...
Substantial reduction in particulate matter air pollution across Europe during 2006-2019: a spatiotemporal modeling analysis (Publications)
results show that during the last 14 years, PM10 and PM2.5 concentrations declined by 36.5% (95% credible interval: 30.3, 41.9%) and 39.1% (26.6, 50.5%), respectively. The number of people exposed to PM10 [...] 6, 91.8%) in 2006 to 28.4% (16.2, 43.7%) in 2019; for PM2.5, the decrease was smaller: from 91.0% (61.3, 99.1%) exposed in 2006 to 53.6% (33.5, 76.3%) in 2019. Although there is a clear improvement in [...] models and for the first time estimate pan-European near-surface concentrations...
Chronic lung function decline in cotton textile workers: roles of historical and recent exposures to endotoxin (Publications)
stratified by active versus retired work status and by years employed before the baseline survey ( < 5 and > or = 5 years). RESULTS AND CONCLUSIONS: Past exposure to endotoxin was associated with reduced FEV1 [...] exposure was more strongly associated with reduced FEV1 for those hired < 5 years before baseline than for those who were hired > or = 5 years after baseline. Recent endotoxin exposure was significantly associated [...] This prospective cohort study followed 447 cotton textile workers...
Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese <em>Ancistrocladus</em> liana and their... (Publications)
further new dimeric analogs, michellamines B4 (3) and B5 (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A1 (5) and A2 (6), which, besides one single known other [...] the highest cytotoxic activities, comparable to that of the standard agent, 5-fluorouracil. Furthermore, ancistrobonsolines A1 (5) and A2 (6) showed weak-to-moderate antiprotozoal activities. [...] Michellamines A6 (1) and A7 (2) are the first dimers of 5,8′-coupled naphthylisoquinoline...
Substantial reduction in particulate matter air pollution across Europe during 2006-2019: a spatiotemporal modeling analysis (Publications)
results show that during the last 14 years, PM10 and PM2.5 concentrations declined by 36.5% (95% credible interval: 30.3, 41.9%) and 39.1% (26.6, 50.5%), respectively. The number of people exposed to PM10 [...] 6, 91.8%) in 2006 to 28.4% (16.2, 43.7%) in 2019; for PM2.5, the decrease was smaller: from 91.0% (61.3, 99.1%) exposed in 2006 to 53.6% (33.5, 76.3%) in 2019. Although there is a clear improvement in [...] models and for the first time estimate pan-European near-surface concentrations...
Long-term exposure to source-specific fine particles and mortality horizontal line a pooled analysis of 14 European cohorts within the ELAPSE project (Publications)
oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure [...] fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through [...] source apportionment analysis. Exposure to 2010 annual average...
Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in... (Publications)
Studies reporting on associations between short-term exposure to outdoor fine (PM2.5), and ultrafine particles (UFP) and blood pressure and lung function have been inconsistent. Few studies have characterized [...] exposure measurement error. We investigated the association between 24-h average personal UFP, PM2.5, and soot exposure and dose and the health parameters blood pressure and lung function. We further assessed [...] residences and these health outcomes. We performed three 24-h personal...
Long-term results of hypofractionated radiotherapy with intra-prostatic boosts in men with intermediate- and high-risk prostate cancer: a phase II... (Publications)
toxicity was low at 6.6% and 5.0%, respectively. Cumulative acute and late urinary toxicity was 49.2% and 30.1%, respectively; the prevalence reduced to 5.9% at 5 years. At 5 years: 6 patients had biochemical [...] biochemical progression (bDFS: 88.5%; 95% CI: 80.2-97.6%), the MFS was 82.4% (95% CI: 73.0-92.9%), 5 patients died (OS: 91.2%; 95% CI: 84.1-98.9%), one with prostate cancer. The prostate, boost, nodal planning [...] were acute (≤18 weeks) and late urinary and gastrointestinal...
Ambient air pollution exposure and cerebral white matter hyperintensities in older adults: a cross-sectional analysis in the Three-City Montpellier... (Publications)
Median exposure to air pollution over the 5 years before MRI acquisition was 24.3 (IQR: 1.7) μg/m3 for PM2.5, 48.9 (14.6) μg/m3 for NO2, and 2.66 (0.60) 10-5/m for BC. We found no significant association [...] volumes. Exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) at the participants' residential address during the 5 years before the MRI examination was estimated with [...] population-based study in older adults, PM2.5 exposure was associated with...