A var gene upstream element controls protein synthesis at the level of translation initiation in <em>Plasmodium falciparum</em> (Publications)
control has recently been identified for the var2csa gene, where an mRNA element in the 5' untranslated region (5' UTR) is involved in the reversible inhibition of translation of var2csa transcripts. Here [...] var gene regulation to the common upsC type. We identified a 5' UTR sequence that inhibits translation of upsC-derived mRNAs. Importantly, this 5' UTR element efficiently inhibits translation even in the [...] epigenetic silencing. Singular gene choice is controlled at the level of...
Long-term exposure to particulate matter constituents and the incidence of coronary events in 11 European cohorts (Publications)
analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 mum (PM10), PM < 2.5 mum (PM2.5), and a [...] increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also
A household-based community health worker programme for non-communicable disease, malnutrition, tuberculosis, HIV and maternal health: a stepped-wedge... (Publications)
interval: -2.5 to 0.5)) while maintaining the already low default rates for HIV patients (0.0 pp, 95% CI: -0.6 to 0.5). First trimester ANC attendance increased by approximately 30% (6.5pp (-0.3, 15.8)) [...] facilities. The intervention roll-out was staggered every 3 months over 18 months, with CHWs receiving a 5-day foundational training for their new tasks and assigned 20-40 households for monthly (or more frequent) [...] 8)) and paediatric malnutrition case finding declined by 10% (-0.6 per...
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled,... (Publications)
(25.8-56.3) in the low-dose group, and 5.2 mug/mL (3.5-7.6) in the placebo group, with respective response rates of 96% (95% CI 85.7-99.5), 96% (86.5-99.5), and 5% (0.1-24.9). Geometric mean concentrations [...] those not deployed, to receive a single intramuscular dose of high-dose vaccine (5 x 1010 viral particles), low-dose vaccine (2.5 x 1010 viral particles), or placebo. Deployed participants were allocated to [...] ions decreased by day 180 to 25.5 mug/mL (95% CI 20.6-31.5) in the...
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled,... (Publications)
(25.8-56.3) in the low-dose group, and 5.2 mug/mL (3.5-7.6) in the placebo group, with respective response rates of 96% (95% CI 85.7-99.5), 96% (86.5-99.5), and 5% (0.1-24.9). Geometric mean concentrations [...] those not deployed, to receive a single intramuscular dose of high-dose vaccine (5 x 1010 viral particles), low-dose vaccine (2.5 x 1010 viral particles), or placebo. Deployed participants were allocated to [...] ions decreased by day 180 to 25.5 mug/mL (95% CI 20.6-31.5) in the...
Outdoor air pollution exposure and cognitive performance: findings from the enrolment phase of the CONSTANCES cohort (Publications)
largest effect size (percentage decrease) for both PM2.5 and NO2 was found for the semantic fluency test (PM2.5 4·6%, 95% CI 2·1–6·9 and NO2 3·8%, 1·9–5·7), whereas for black carbon, the largest effect size [...] regression models, to assign exposure to particulate matter with aerodynamic diameters less than 2·5 μm (PM2·5), nitrogen dioxide (NO2), and black carbon. We used multiple linear regression models with different [...] to PM2·5 was mainly significant for the semantic fluency test. We...
Serological study of <em>Leptospira interrogans</em> serovar Copenhageni and <em>L. borgpetersenii</em> serovars Tarassovi and Ballum in beef cattle,... (Publications)
and 18.0 (95% CI=15.7-20.5)% for beef cattle, 10.5 (95% CI=9.0-12.1)%, 16.7 (95% CI=14.9-18.6)% and 14.0 (95% CI=12.4-15.8)% for sheep and 6.6 (95% CI=5.3-8.2)%, 15.5 (95% CI=13.5-17.7)% and 3.6 (95% CI=2 [...] 95.1, 73.2 and 56.1% for sheep, 68.5, 48.2 and 29.6% for beef cattle and 73.8, 57.4 and 41.0% for deer, and for Tarassovi, 80.5, 59.7 and 45.1% for sheep, 83.3, 68.5 and 61.1% for beef cattle, and 42.6 [...] animal species and all five Leptospira serovars was 100% at definition > /=1...
Seasonality of mortality under climate change: a multicountry projection study (Publications)
high-emission scenarios (SSP3-7.0 and SSP5-8.5), substantially altering the shape of seasonality of mortality and, under the highest emission scenario (SSP5-8.5), shifting the mortality peak from cold seasons [...] to increasing emissions (Shared Socioeconomic Pathways [SSP] scenarios SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5). We compared the seasonality in projected mortality between decades by its shape, timings [...] from 0·96 to 1·11, and the change in attributable fraction ranged from...
Outdoor air pollution exposure and cognitive performance: findings from the enrolment phase of the CONSTANCES cohort (Publications)
effect size (percentage decrease) for both PM(2.5) and NO(2) was found for the semantic fluency test (PM(2.5) 4.6%, 95% CI 2.1-6.9 and NO(2) 3.8%, 1.9-5.7), whereas for black carbon, the largest effect [...] regression models, to assign exposure to particulate matter with aerodynamic diameters less than 2.5 mum (PM(2.5)), nitrogen dioxide (NO(2)), and black carbon. We used multiple linear regression models with [...] to PM(2.5) was mainly significant for the semantic fluency test. We found that...
Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter (Publications)
microg/m3 1-hr maximum personal PM, -6.0% (-10.5 to -1.4); 30 microg/m3 24-hr average personal PM, -5.9% (-10.8 to -1.0); 6.7 microg/m3 indoor home PM2.5, -1.6% (-2.8 to -0.4); 16 microg/m3 indoor home [...] home PM10, -2.1% (-3.7 to -0.4); 7.1 microg/m3 outdoor home PM2.5, -1.1% (-2.4 to 0.1); and 7.5 microg/m3 central-site PM2.5, -0.7% (-1.9 to 0.4). Stronger associations were found for multiday moving averages [...] carried by subjects; indoor, outdoor home, and central-site 24-hr gravimetric...
