National and sub-national exposure to ambient fine particulate matter PM2.5 and its attributable burden of disease in Iran from 1990 to 2016 (Publications)
Ambient particulate matter is a public health concern. We aimed (1) to estimate national and provincial long-term exposure of Iranians to ambient particulate matter (PM)
Bayesian conditional autoregressive models to assess spatial patterns of diarrhoea risk among children under the age of 5 years in Mbour, Senegal. (Publications)
were analysed to describe the spatial pattern of diarrhoeal prevalence in children under the age of 5 years in the secondary city of Mbour in the south-western part of Senegal. Bayesian conditional aut
Validation of <em>Plasmodium falciparum</em> dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity (Publications)
and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5'-triphosphate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within [...] construct could recombine correctly in the locus suggesting that the enzyme is essential. The four 5'-tritylated deoxyuridine analogues described are potent inhibitors of the P. falciparum dUTPase and
Comparison of next-generation portable pollution monitors to measure exposure to PM2.5 from household air pollution in Puno, Peru (Publications)
exposure to PM2.5 is critical for understanding intervention effectiveness and exposure-response relationships in household air pollution studies. In this pilot study, we compared PM2.5 concentrations obtained
O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis (Publications)
microscopy, O-150 qPCR, and the novel O-5S qPCR. RESULTS: Among the 200 individuals, 133 patients tested positive (positivity rate of 66.5%) and 67 negative by O-5S qPCR, 74 tested positive by microscopy [...] individuals who tested negative by O-5S qPCR tested positive by microscopy or O-150 qPCR, implying 100% specificity of the newly designed O-5S qPCR assay. CONCLUSIONS: The novel O-5S qPCR assay is more sensitive [...] qPCR (39.0%). Among the 133 O-5S qPCR positive individuals, microscopy...
Long-term exposures to PM2.5, black carbon and NO2 and prevalence of current rhinitis in French adults: the constances cohort (Publications)
BACKGROUND: Rhinitis is one of the most common disease worldwide with a high and increasing prevalence. There is limited knowledge on the link between long-term exposure to air pollution and rhinitis.
<em>In vitro, in vivo</em>, and ADME evaluation of SF5-containing <em>N,N'</em>-diarylureas as antischistosomal agents (Publications)
at 10 μM), endowed with decent cytotoxicity profile (SI against L6 cells > 8.5) and good microsomal hepatic stability (> 62.5% of drug remaining after 60 min), were tested in S. mansoni infected mice. Despite [...] found. Thus, further investigations are needed to better understand the underlying mechanisms of SF(5)-containing N,N'-diarylureas.
Common haplotypes at the <em>CFH </em>locus and low-frequency variants in <em>CFHR2 </em>and <em>CFHR5 </em>associate with systemic FHR concentrations... (Publications)
in CFHR2 and CFHR5 led to reduced or absent FHR-2 and FHR-5 concentrations (e.g., p.Cys72Tyr in CFHR2 and FHR-2, p = 2.46 x 10(-16)). Finally, we showed localization of FHR-2 and FHR-5 in the choriocapillaris [...] and rare protein-altering CFHR2 and CFHR5 variants associated with AMD independently of all previously reported genome-wide association study (GWAS) signals (p = 5.03 x 10(-3) and p = 2.81 x 10(-6), res [...] elevated systemic levels of FHR-1 (p = 1.84 x 10(-6)), FHR-2 (p = 1.47 x...
<em>Mycobacterium tuberculosis </em>complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to... (Publications)
absent between H37Rv and L5 strains. Additionally, considerable gene content variability was found across L5 strains, including a split in the L5.3 sub-lineage into L5.3.1 and L5.3.2. These gene content [...] lineages (L), especially L5 and L6 (traditionally termed Mycobacterium africanum) strains, from each other. However, this genome variability and gene content, especially of L5 strains, has not been fully [...] genomic analysis of MTBC strains, including transmission studies. By comparing...