MOSASWA Modelling Support (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/mosaswa-modelling-support
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Lignans, amides, and saponins from <em>Haplophyllum tuberculatum</em> and their antiprotozoal activity (Publications)
loyltyramine (5), (E)-N-feruloyltyramine (6), N,N'-diferuloylputrescine (8), and 7'-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11-13. Compounds 1, 2, and 5-13 are reported [...] Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 microM) and the highest selectivity index (25.5).
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
stant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing [...] n. Pf_proteasome purification was facilitated by His(8)-tag introduction onto β7. Inhibition of Pfβ5 correlated with parasite killing, without inhibiting human proteasome isoforms or showing cytotoxicity [...] that SW584 bound non-covalently distal from the catalytic threonine, in an...
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
stant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing [...] n. Pf_proteasome purification was facilitated by His(8)-tag introduction onto β7. Inhibition of Pfβ5 correlated with parasite killing, without inhibiting human proteasome isoforms or showing cytotoxicity [...] that SW584 bound non-covalently distal from the catalytic threonine, in an...
Lignans, amides, and saponins from <em>Haplophyllum tuberculatum</em> and their antiprotozoal activity (Publications)
loyltyramine (5), (E)-N-feruloyltyramine (6), N,N'-diferuloylputrescine (8), and 7'-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11-13. Compounds 1, 2, and 5-13 are reported [...] Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 microM) and the highest selectivity index (25.5).
Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts... (Publications)
8-19.5), we observed 6950 incident events of stroke and 10 071 incident events of coronary heart disease. Incidence of stroke was associated with PM2.5 (hazard ratio 1.10 [95% CI 1.01-1.21] per 5 mug/m(3) [...] increase), NO2 (1.08 [1.04-1.12] per 10 mug/m(3) increase), and black carbon (1.06 [1.02-1.10] per 0.5 10(-5)/m increase), whereas coronary heart disease incidence was only associated with NO2 (1.04 [1.01-1 [...] estimates for PM2.5 and NO2 remained elevated even when restricting analyses...
Identifying risk factors for <em>Plasmodium </em>infection and anaemia in Kinshasa, Democratic Republic of Congo (Publications)
lower transmission HZs (p = 0.009). In a separate analysis in children over 5 years in two selected HZs, the peak prevalence was in 5-9 years old in the higher transmission setting and in 15-19 years old in [...] associated with Plasmodium infection and anaemia among children 6-59 months and individuals aged older than 5 years in Kinshasa, a large city with heterogeneity in malaria prevalence. METHODS: This study analysed [...] children aged 6-59 months from 25 non-rural health zones (HZs) and...
Identifying risk factors for <em>Plasmodium </em>infection and anaemia in Kinshasa, Democratic Republic of Congo (Publications)
lower transmission HZs (p = 0.009). In a separate analysis in children over 5 years in two selected HZs, the peak prevalence was in 5-9 years old in the higher transmission setting and in 15-19 years old in [...] associated with Plasmodium infection and anaemia among children 6-59 months and individuals aged older than 5 years in Kinshasa, a large city with heterogeneity in malaria prevalence. METHODS: This study analysed [...] children aged 6-59 months from 25 non-rural health zones (HZs) and...
Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts... (Publications)
8-19.5), we observed 6950 incident events of stroke and 10 071 incident events of coronary heart disease. Incidence of stroke was associated with PM2.5 (hazard ratio 1.10 [95% CI 1.01-1.21] per 5 mug/m(3) [...] increase), NO2 (1.08 [1.04-1.12] per 10 mug/m(3) increase), and black carbon (1.06 [1.02-1.10] per 0.5 10(-5)/m increase), whereas coronary heart disease incidence was only associated with NO2 (1.04 [1.01-1 [...] estimates for PM2.5 and NO2 remained elevated even when restricting analyses...
Evaluating implementation of LEAPS, a youth-led early childhood care and education intervention in rural Pakistan: protocol for a stepped wedge... (Publications)
youth, 18-24 years, as Community Youth Leaders (CYLs) to deliver high-quality ECCE for children, 3.5-5.5 years, in rural Sindh, Pakistan. METHODS: We use a stepped wedge cluster-randomized trial to evaluate [...] collected in cross-sectional surveys of 1089 children (11 children/cluster from 99 clusters) aged 4.5-5.5 years at four timepoints (baseline and at the end of each step). Additionally, we will enroll three [...] across multiple SDG targets. TRIAL REGISTRATION: ClinicalTrials.gov...
