Geographical variation in the association of child, maternal and household health interventions with under-five mortality in Burkina Faso (Publications)
mortality rates (U5MR) in sub-Saharan Africa. However, the reduction shows considerable heterogeneity. We estimated the association of child, maternal, and household interventions with U5MR in Burkina Faso [...] health interventions with U5MR. The analyses were adjusted for child, maternal, and household characteristics, as well as climatic and environmental factors. FINDINGS: The average U5MR was as high as 128 per [...] the regions with least effective interventions. METHODS: Data on...
Geographical variation in the association of child, maternal and household health interventions with under-five mortality in Burkina Faso (Publications)
mortality rates (U5MR) in sub-Saharan Africa. However, the reduction shows considerable heterogeneity. We estimated the association of child, maternal, and household interventions with U5MR in Burkina Faso [...] health interventions with U5MR. The analyses were adjusted for child, maternal, and household characteristics, as well as climatic and environmental factors. FINDINGS: The average U5MR was as high as 128 per [...] the regions with least effective interventions. METHODS: Data on...
Evaluating implementation of LEAPS, a youth-led early childhood care and education intervention in rural Pakistan: protocol for a stepped wedge... (Publications)
youth, 18-24 years, as Community Youth Leaders (CYLs) to deliver high-quality ECCE for children, 3.5-5.5 years, in rural Sindh, Pakistan. METHODS: We use a stepped wedge cluster-randomized trial to evaluate [...] collected in cross-sectional surveys of 1089 children (11 children/cluster from 99 clusters) aged 4.5-5.5 years at four timepoints (baseline and at the end of each step). Additionally, we will enroll three [...] across multiple SDG targets. TRIAL REGISTRATION: ClinicalTrials.gov...
Antitrypanosomal sesquiterpene lactones from <em>Saussurea costus</em> (Publications)
lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22muM. Cytotoxic IC(50)s were from 1.6 to 19muM, and selectivity indices from 0.5 to 6.5
Cytotoxic benzil and coumestan derivatives from <em>Tephrosia calophylla</em> (Publications)
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'', 3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and [...] against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively
Cytotoxic benzil and coumestan derivatives from <em>Tephrosia calophylla</em> (Publications)
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'', 3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and [...] against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC(50) of 5.00 (RAW) and 2.90microM (HT-29), respectively
Antitrypanosomal sesquiterpene lactones from <em>Saussurea costus</em> (Publications)
lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22muM. Cytotoxic IC(50)s were from 1.6 to 19muM, and selectivity indices from 0.5 to 6.5
Air pollution and human health: a phenome-wide association study (Publications)
(PM(2.5): 1.06 (95% CI 1.05 to 1.06); NO(2): 1.12 (95% CI 1.10 to 1.13)) and ischaemic heart disease (PM(2.5): 1.05 (95% CI 1.04 to 1.05); NO(2): 1.11 (95% CI 1.09 to 1.12)). Furthermore, PM(2.5) and NO(2) [...] As regards the most common health conditions, PM(2.5) and NO(2) were strongest positively associated with chronic obstructive pulmonary disease (PM(2.5): HR 1.06 (95% CI 1.05 to 1.07) per 1 IQR increase [...] Diseases, 10th revision, from 2000 to 2017. RESULTS: Long-term exposure to fine...
Association of air pollution with incidence of end-stage kidney disease in two large European cohorts (Publications)
association between PM(2.5) or O(3) and ESKD. There were elevated HRs but with large confidence intervals for BC (HR 1.17 [95 % confidence interval (CI): 0.98, 1.39] for 0.5*10(-5)/m), and for NO₂ (HR 1 [...] [95%CI: 0.96, 1.35] for 10 μg/m(3)). In RoLS, ESKD was associated with PM(2.5) (HR 1.37 [95 % CI: 1.06, 1.76] for an increase of 5 μg/m(3)), while there was no evidence of association with BC, NO(2), or O(3) [...] investigated the association of long-term exposure to nitrogen dioxide (NO₂),...
Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide... (Publications)
BACKGROUND: Fine particulate matter (PM(2.5)) is a well-recognized risk factor for premature death. However, evidence on which PM(2.5) components are most relevant is unclear. METHODS: We evaluated the [...] the associations between mortality and long-term exposure to eight PM(2.5) elemental components [copper (Cu), iron (Fe), zinc (Zn), sulfur (S), nickel (Ni), vanadium (V), silicon (Si), and potassium (K)] [...] regression models at a 100 x 100 m scale to estimate the residential annual mean...
