Microsatellite and mitochondrial genetic differentiation of <em>Anopheles arabiensis</em> (Diptera: Culicidae) from western Kenya, the Great Rift... (Publications)
investigated using 12 microsatellite loci and a partial sequence of mtDNA dehydrogenase gene subunit 5 (ND5). The mean number of alleles and the observed heterozygosity were similar for the mosquito populations [...] the three regions as revealed by the microsatellite data. A total of 30 polymorphic sites in the ND5 gene defined 39 haplotypes. Six haplotypes were shared among four populations from the three distinct [...] markers outside inversions (F(ST) = 0.016) or inside fixed inversions...
Microsatellite and mitochondrial genetic differentiation of <em>Anopheles arabiensis</em> (Diptera: Culicidae) from western Kenya, the Great Rift... (Publications)
investigated using 12 microsatellite loci and a partial sequence of mtDNA dehydrogenase gene subunit 5 (ND5). The mean number of alleles and the observed heterozygosity were similar for the mosquito populations [...] the three regions as revealed by the microsatellite data. A total of 30 polymorphic sites in the ND5 gene defined 39 haplotypes. Six haplotypes were shared among four populations from the three distinct [...] markers outside inversions (F(ST) = 0.016) or inside fixed inversions...
Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) kappabeta pathway) and GNG5P5, respectively. Single nucleotide polymorphisms [...] polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p = 9.96x10-9). The second replication phase, in seven independent cohorts, provided no significant
Chronic bronchitis and urban air pollution in an international study (Publications)
prevalence and new onset of chronic phlegm during the follow-up were 6.9% and 4.5%, respectively, in males and 5.3% and 3.5% in females. Smoking, rhinitis, poor education and low social class showed associations [...] follow- from the years 2000 to 2002 (n = 3232 males and 3592 females; average response rate = 65.3%). PM2.5 and elements, with the same equipment at centre level, and home outdoor NO2 in 1,634 individuals were [...] 77) as well as home outdoor NO2 (OR > 50 ig/m3 versus < 20 ig3 =...
Arginine and lysine transporters are essential for <em>Trypanosoma brucei</em> (Publications)
high affinity (Km 4.3 +/- 0.5 muM) and highly selective L-lysine transporter and of the compounds tested, only L-lysine and thialysine were competing for L-lysine uptake. TbAAT5-3 and TbAAT16-1 are expressed [...] plasma membrane. RNAi-mediated down-regulation of TbAAT5 and TbAAT16 in bloodstream form trypanosomes resulted in growth arrest, demonstrating that TbAAT5-mediated arginine and TbAAT16-mediated lysine transport [...] amino acid transporters among members of the T. brucei AAAP (amino...
A pilot study characterizing real time exposures to particulate matter and carbon monoxide from cookstove related woodsmoke in rural Peru (Publications)
Cajamarca Region, Peru. Real time personal particulate matter with an aerodynamic diameter ?2.5 ?m (PM2.5), and personal and kitchen carbon monoxide (CO) samples were taken. Control households used a number [...] personal PM2.5 exposures were correlated with personal CO exposures during lunch (r = 0.67 p = 0.024 n = 11) and dinner (r = 0.72 p = 0.0011 n = 17) in all study households. Personal PM2.5 exposures and [...] pollution (HAP) due to long hours spent in close proximity to unvented cooking...
Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of... (Publications)
fever. Geographical proximity (AOR = 1.5, 95% CI 1.2-2.1), having a child under five (AOR = 4.6, 95% CI 3.2-6.7), being pregnant (AOR = 6.5, 95% CI 1.9-22.5), and living in an urban area (AOR = 2.8, 95% [...] sought advice or treatment, and 66.5% did so within 24 h of fever onset. 76.4% of participants preferred to seek treatment from health centres as the first recourse to care, 5.8% were treated at home with remaining [...] Multivariate analysis identified less than 5 km distance travelled...
Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of... (Publications)
fever. Geographical proximity (AOR = 1.5, 95% CI 1.2-2.1), having a child under five (AOR = 4.6, 95% CI 3.2-6.7), being pregnant (AOR = 6.5, 95% CI 1.9-22.5), and living in an urban area (AOR = 2.8, 95% [...] sought advice or treatment, and 66.5% did so within 24 h of fever onset. 76.4% of participants preferred to seek treatment from health centres as the first recourse to care, 5.8% were treated at home with remaining [...] Multivariate analysis identified less than 5 km distance travelled...
Nutritional status of Tajik children and women: transition towards a double burden of malnutrition (Publications)
iron deficiency and anaemia was 38.0% and 25.8%, respectively; 64.5% of women were iodine deficient, 46.5% vitamin A deficient, and 20.5% had insufficient folate levels. Women in rural areas had significantly [...] and population. Here, we explore the nutritional status of Tajik women (15-49 years) and children (5-59 months) focusing on overweight/obesity along with undernutrition (underweight, stunting, and mic [...] weaning, and breastfeeding habits were recorded using a 24-hr recall and a...
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5mug.m(-3) of [...] (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the [...] of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional...