Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
response. Malaria infection was via 5 bites of Plasmodium falciparum-infected mosquitos, with individuals reaching patent infection by 11-12 days, having harboured 4-5 blood stage cycles prior to drug clearance [...] demonstrated pre-existing IFNgamma, IL-2 and IL-5 ELIspot responses against the influenza antigens, and showed boosting of anti-influenza T cell responses only for IL-5. The large IgG1-dominated anti-parasite [...] T cell responses for magnitude or avidity, both parameters being...
Antibody and T cell responses associated with experimental human malaria infection or vaccination show limited relationships (Publications)
response. Malaria infection was via 5 bites of Plasmodium falciparum-infected mosquitos, with individuals reaching patent infection by 11-12 days, having harboured 4-5 blood stage cycles prior to drug clearance [...] demonstrated pre-existing IFNgamma, IL-2 and IL-5 ELIspot responses against the influenza antigens, and showed boosting of anti-influenza T cell responses only for IL-5. The large IgG1-dominated anti-parasite [...] T cell responses for magnitude or avidity, both parameters being...
Association between air pollution and rhinitis incidence in two European cohorts (Publications)
increase of 5mug.m(-3) of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10mug.m(-3) of NO2: 1.01 [0.87-1.17], for an increase of 5mug.m(-3) of [...] (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the [...] of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional...
Nutritional status of Tajik children and women: transition towards a double burden of malnutrition (Publications)
iron deficiency and anaemia was 38.0% and 25.8%, respectively; 64.5% of women were iodine deficient, 46.5% vitamin A deficient, and 20.5% had insufficient folate levels. Women in rural areas had significantly [...] and population. Here, we explore the nutritional status of Tajik women (15-49 years) and children (5-59 months) focusing on overweight/obesity along with undernutrition (underweight, stunting, and mic [...] weaning, and breastfeeding habits were recorded using a 24-hr recall and a...
Joint effect of heat and air pollution on mortality in 620 cities of 36 countries (Publications)
daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM10), PM ≤ 2.5 μm (PM2.5), nitrogen dioxide (NO2), and ozone (O3) from 620 cities in 36 countries in the period 1995-2020 [...] ng estimates when daily O3 concentrations were 40 or 160 μg/m3 were 2.9% (1.1%, 4.7%) and 12.5% (6.9%, 18.5%), respectively. Similarly, a 10 μg/m3 increment in PM10 was associated with a 0.54% (0.10%, [...] associated with an average 8.9% (95% confidence interval: 7.1%, 10.7%) mortality...
Characterization of particulate matter emission from open burning of rice straw (Publications)
majority of PM emitted from the field burning was PM(2.5) with EF of 5.1+/-0.7 g m(-2) or 8.3+/-2.7 g kg(-1) RS burned. The coarse PM fraction (PM(10-2.5)) was mainly generated by fire attention activities [...] activities and was relatively small, hence the resulting EF of PM(10) (9.4+/-3.5 g kg(-1) RS) was not significantly higher than PM(2.5). PM size distribution was measured across 8 size ranges (from 9.0 mum). The [...] largest fractions of PM, EC and OC were associated with PM(1.1). The...
Long-term exposure to fine particle elemental components and mortality in Europe: results from six European administrative cohorts within the ELAPSE... (Publications)
PM2.5 or NO2 adjustment [pooled HRs (95% CI) per 50ng/m(3) in K: 1.025 (1.008, 1.044), 1.020 (0.999, 1.042) and per 100ng/m(3) in Si: 1.121 (1.039, 1.209), 1.068 (1.022, 1.117) adjusted for PM2.5 and NO2 [...] nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn) in fine particulate matter (PM2.5) were estimated using 100x100m Europe-wide hybrid land use regression models assigned to the participants' [...] covariates to evaluate associations with natural mortality. Two pollutant...
Preventing dehydration in children with cystic fibrosis who exercise in the heat (Publications)
kg(-1) (P < 0.0005), serum sodium from 143.1 +/- 0.5 to 141.1 +/- 0.7 mmol x L(-1) (P = 0.01) and serum chloride from 109.1 +/- 0.5 to 107.5 +/- 0.5 mmol X L(-1) (P < 0.001). In contrast, the 50 mmol x [...] NaCl concentration higher than 18 mmol x L(-1). METHODS: Eleven subjects with CF (6 girls, 5 boys, ages 10.9-19.5 yr) attended three 3-h sessions of intermittent exercise of moderate intensity (four 20-min
Joint effect of heat and air pollution on mortality in 620 cities of 36 countries (Publications)
daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM(10)), PM ≤ 2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)), and ozone (O(3)) from 620 cities in 36 countries in the period 1995-2020 [...] estimates when daily O(3) concentrations were 40 or 160 μg/m(3) were 2.9 % (1.1 %, 4.7 %) and 12.5 % (6.9 %, 18.5 %), respectively. Similarly, a 10 μg/m(3) increment in PM(10) was associated with a 0.54 % (0 [...] with an average 8.9 % (95 % confidence interval: 7.1 %, 10.7 %)...
Cardiorespiratory hospitalisation and mortality reductions after smoking bans in Switzerland (Publications)
detected in ischaemic heart disease hospitalisations, with a 2.5% reduction (95% confidence interval [CI)] -6.2 to 1.3%) for all ages and 5.5% (95% CI -10.8 to -0.2%) in adults 35-64 years old. Total mortality [...] post-ban reductions in mortality due to hypertensive disorders (-5.4%, 95% CI -12.6 to 2.3%), and congestive heart failure (-6.0%, 95% CI -14.5 to 3.4%). No benefits were observed for hospitalisations due [...] all ages, and chronic obstructive pulmonary disease mortality decreased...