Mortality risk attributable to wildfire-related PM2.5 pollution: a global time series study in 749 locations (Publications)
between wildfire-related PM2.5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2.5 and mortality across various [...] wildfire-related PM2.5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0.25 degrees x 0.25 degrees resolution. The association between wildfire-related PM2.5 exposure and mortality [...] attributable to the acute impacts of wildfire-related PM2.5...
Effectiveness of school-based preventive chemotherapy strategies for sustaining the control of schistosomiasis in Côte d’Ivoire: results of a 5-year... (Publications)
thick smears, among children aged 9-12 years at the time of each survey. First-grade children, aged 5-8 years who had never received praziquantel, were also tested at baseline and at the end of the study [...] final year, we observed the lowest prevalence of 10.4% in arm 1, compared to 18.2% in arm 2 and 17.5% in arm 3. The comparison between arms 1 and 2 estimated an odds ratio (OR) of 0.52 but the difference [...] final year survey were observed in arm 1 (7.9 eggs per gram of stool (EPG))....
NO2 and PM2.5 exposures and lung function in Swiss adults: estimated effects of short-term exposures and long-term exposures with and without... (Publications)
-18.5 ml [-26.5, -10.5]). A 10mug/m3 increase in 1-y mean NO2 was also associated with lower FEV1 (-7.7 ml; -15.9, 0.5) and FVC (-21.6 ml; -31.9, -11.4), as was a 10mug/m3 increase in 1-y mean PM2.5 (FEV1: [...] dioxide (NO2) and particulate matter with an aerodynamic diameter of less than or equal to 2.5. microns (PM2.5) exposures on lung function has been investigated mainly in children and less in adults. Furthermore [...] NO2 and PM2.5 on the day of the pulmonary function test was associated...
Evaluation of the ERA5 reanalysis-based universal thermal climate index on mortality data in Europe (Publications)
ERA5 – the latest global climate reanalysis from the European Centre for Medium-Range Weather Forecasts (ECMWF) – as a health-related tool. Employing a novel ERA5-based thermal comfort dataset ERA5-HEAT [...] performance of ERA5-based UTCI, we compared its effects on mortality with those for the station-based UTCI data. In order to assess the additional effect of the UTCI, the performance of ERA5-and station-based [...] UTCI distribution. The comparison of exposure-response relationships between...
Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic... (Publications)
facility workers), with caregivers of children < 5 years of age during three household surveys (N = 9332 caregivers), and with caregivers of children < 5 years of age who were treated with RAS and enrolled
Genome-wide analyses identify <em>SCN5A</em> as a susceptibility locus for premature atrial contraction frequency (Publications)
European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard [...] there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 x 10(-5)). However, several AF risk loci, including PITX2, were not associated with PAC frequency. These
Effects of climatic factors on diarrheal diseases among children below 5 years of age at national and subnational levels in Nepal: an ecological study (Publications)
prominent at the national level (11.63% rise in diarrheal cases in summer (95% CI: 4.17, 19.61) and 14.5% decrease in spring (95% CI: -18.81, -10.02) compared to winter season). Moreover, the effects of t
CD38 expression by antigen-specific CD4 t cells is significantly restored 5 months after treatment initiation independently of sputum bacterial load... (Publications)
patient. We recruited 105 Tanzanian adult tuberculosis (TB) patients and obtained blood before and after 5 months of antibiotic treatment. We studied relationships between patients' clinical characteristics [...] CD27, the resolution of CD38 expression by antigen-specific T cells was observed readily following 5 months of antibiotic therapy. However, the intensity of CD38-TAM signals measured at diagnosis did not
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by