Diaryl ureas as an antiprotozoal chemotype (Publications)
potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models
Diaryl ureas as an antiprotozoal chemotype (Publications)
potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models
<em>Trypanosoma brucei </em>CTP synthetase: a target for the treatment of African sleeping sickness (Publications)
the lack of salvage pathways. The CTP synthetase inhibitors 6-diazo-5-oxo-l-norleucine (DON) and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin) reduced the parasite CTP levels even
<em>ent</em>-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the... (Publications)
1'-coupled ent-dioncophylleine A (3a), the likewise 7,1'-coupled 5'-O-demethyl-ent-dioncophylleine A (4), and the 7,8'-linked dioncophylleine D (5), have been isolated from the leaves of the recently described [...] only axially chiral, naphthylisoquinoline alkaloids of this type that are optically active; compound 5, by contrast, is fully racemic, due to its configurationally unstable biaryl axis. The structural e
<em>Trypanosoma brucei </em>CTP synthetase: a target for the treatment of African sleeping sickness (Publications)
the lack of salvage pathways. The CTP synthetase inhibitors 6-diazo-5-oxo-l-norleucine (DON) and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin) reduced the parasite CTP levels even
<em>ent</em>-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the... (Publications)
1'-coupled ent-dioncophylleine A (3a), the likewise 7,1'-coupled 5'-O-demethyl-ent-dioncophylleine A (4), and the 7,8'-linked dioncophylleine D (5), have been isolated from the leaves of the recently described [...] only axially chiral, naphthylisoquinoline alkaloids of this type that are optically active; compound 5, by contrast, is fully racemic, due to its configurationally unstable biaryl axis. The structural e
Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey (Publications)
Among younger participants (18-29 y), 16.1% reported tobacco use, 28.6% were overweight, 1.5% had diabetes and 3.5% had elevated BP. Household wealth positively correlated with the prevalence of elevated [...] overall prevalence of overweight, diabetes, elevated blood pressure (BP) and tobacco use was 39.9%, 5.3%, 21.6% and 24.9%, respectively. Among participants, 34.6% had none, 45.2% had one and 20.2% had two [...] two or more CVDRFs. Women were more likely to have two or more CVDRFs (20.7% vs...
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (Publications)
meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected [...] the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 x 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and
Influence of pacing manipulation on performance of juniors in simulated 400 m swim competition (Publications)
time was faster in PPSS (275.0+/-15.9 s) compared with PPfast (278.5+/-16.4 s, (p=0.05) but not significantly different to PPslow (277.5+/-16.2 s, p=0.22). However, analysis for practical relevance revealed [...] influence of PP manipulation on 400 m freestyle swimming performance. METHODS: 15 front-crawl swimmers (5 female, 10 male, age: 18+/-2 y) performed three simulated 400 m swimming events. The initial trial was [...] in a counter-balanced order and required participants to complete the...
The global burden of disease due to outdoor air pollution (Publications)
air pollution, in terms of fine particulate air pollution (PM(2.5)), causes about 3% of mortality from cardiopulmonary disease, about 5% of mortality from cancer of the trachea, bronchus, and lung, and [...] from acute respiratory infections in children under 5 yr, worldwide. This amounts to about 0.8 million (1.2%) premature deaths and 6.4 million (0.5%) years of life lost (YLL). This burden occurs predominantly