The global burden of disease due to outdoor air pollution (Publications)
air pollution, in terms of fine particulate air pollution (PM(2.5)), causes about 3% of mortality from cardiopulmonary disease, about 5% of mortality from cancer of the trachea, bronchus, and lung, and [...] from acute respiratory infections in children under 5 yr, worldwide. This amounts to about 0.8 million (1.2%) premature deaths and 6.4 million (0.5%) years of life lost (YLL). This burden occurs predominantly
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (Publications)
meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected [...] the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 x 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and
Influence of pacing manipulation on performance of juniors in simulated 400 m swim competition (Publications)
time was faster in PPSS (275.0+/-15.9 s) compared with PPfast (278.5+/-16.4 s, (p=0.05) but not significantly different to PPslow (277.5+/-16.2 s, p=0.22). However, analysis for practical relevance revealed [...] influence of PP manipulation on 400 m freestyle swimming performance. METHODS: 15 front-crawl swimmers (5 female, 10 male, age: 18+/-2 y) performed three simulated 400 m swimming events. The initial trial was [...] in a counter-balanced order and required participants to complete the...
Prevalence and determinants of cardiovascular risk factors in Lesotho: a population-based survey (Publications)
Among younger participants (18-29 y), 16.1% reported tobacco use, 28.6% were overweight, 1.5% had diabetes and 3.5% had elevated BP. Household wealth positively correlated with the prevalence of elevated [...] overall prevalence of overweight, diabetes, elevated blood pressure (BP) and tobacco use was 39.9%, 5.3%, 21.6% and 24.9%, respectively. Among participants, 34.6% had none, 45.2% had one and 20.2% had two [...] two or more CVDRFs. Women were more likely to have two or more CVDRFs (20.7% vs...
Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase... (Publications)
n malaria setting in western Kenya ( NCT02687373 ). Groups of 84 infants each received 4.5 x 10(5), 9.0 x 10(5) or 1.8 x 10(6) PfSPZ Vaccine or saline three times at 8-week intervals. The vaccine was well [...] protection against P. falciparum infection in any dose group at 6 months (VE in the 9.0 x 10(5) dose group = -6.5%, P = 0.598, the primary statistical end point of the study). VE against clinical malaria [...] . We conducted a multi-arm, randomized, double-blind, placebo-controlled trial...
Associations of air pollution and greenness with the nasal microbiota of healthy infants: a longitudinal study (Publications)
(SD) PM2.5 level was 17.1 (3.8mug/m(3)) and mean (SD) NO2 level was 19.7 (7.9mug/m(3)). Increased PM2.5 and increased NO2 were associated with reduced within-subject Ruzicka dissimilarity (PM2.5: per 1mug/m(3) [...] long-term respiratory health. We aimed to examine associations between fine particulate matter (PM2.5), nitrogen dioxide (NO2) and greenness with the nasal microbiota of healthy infants during the first [...] d the association of satellite-based greenness and an 8-day-average...
Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: beyond mortality from cardiopulmonary disease... (Publications)
exposure to PM2.5 (mean: 12.4 microg/m(3)), NO2 (20.3 microg/m(3)), and/or BC (1.0 x 10(-5)/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 microg/m(3) increase [...] from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide [...] increase in PM2.5 was associated with higher mortality from...
Incidence and risk factors of surgical site infections and related antibiotic resistance in Freetown, Sierra Leone: a prospective cohort study (Publications)
patients, 245 (72.5%) and 93 (27.5%) had their surgeries at the tertiary and secondary hospitals, respectively. Many were males 192 (56.8%), less than 35 years 164 (48.5%), and 39 (11.5%) developed an SSI [...] Enterococci. The most common isolates were Escherichia coli (12, 24.5%), Klebsiella pneumoniae (10, 20.4%), Acinetobacter baumannii (5, 10.2%), Klebsiella oxytoca (4, 8.2%) and Enterococcus faecalis (4
Canine leptospirosis in Switzerland-a prospective cross-sectional study examining seroprevalence, risk factors and urinary shedding of pathogenic... (Publications)
1%; 95%CI 3.7-8.5), Canicola (5%; 95%CI 2.9-7.4), Grippotyphosa (4.5%; 95%CI 2.7-6.9), Pomona (4%; 95%CI 2.1-6.1), Autumnalis (2.7%; 95%CI 1.3-4.2) and Icterohaemorrhagiae (1.6%; 95%CI 0.5-2.9). In unvaccinated [...] /=1:40) to any serovar included age (OR 1.29/year; 95%CI: 1.1-1.5) and bioregion with higher risks in the regions Northern Alps (OR 14.5; 95%CI 2.2-292.7), Central Plateau (OR 12.3; 95%CI 2.0-244.1) and
A comparison of linear regression, regularization, and machine learning algorithms to develop Europe-wide spatial models of fine particles and... (Publications)
measured at 416 (PM2.5) and 1396 sites (NO2) from the ESCAPE study. We further assessed the correlations between predictions by each pair of algorithms at the ESCAPE sites. For PM2.5, the models performed [...] predictive ability. This study compared 16 algorithms to predict annual average fine particle (PM2.5) and nitrogen dioxide (NO2) concentrations across Europe. The evaluated algorithms included linear stepwise [...] monitoring data from the AIRBASE dataset maintained by the European...