Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of <em>Triphyophyllum peltatum</em> (Dioncophyllaceae) and... (Publications)
Dioncoquinones A (4) and B (5) showed good - and specific - activity against Leishmania major, while they were not active against other protozoic parasites. Moreover, treatment with 4 and 5 strongly induced apoptosis [...] and Ancistrocladaceae seven new natural naphthoquinones were isolated, dioncoquinones A (4) and B (5) from Triphyophyllum peltatum, and ancistroquinones B (6), C (7), D (9), E (10), and F (12) from An
Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland (Publications)
prevalences of C parvum, rotavirus, BCV and E coli k99 were 55.0 per cent, 58.7 per cent, 7.8 per cent and 5.5 per cent, respectively. The proportions of herds positive for the respective pathogens among the herds [...] 52.1 per cent, 2.1 per cent and 2.1 per cent. The immunoglobulin concentration in the serum of 90.5 per cent of the diarrhoeic calves was below 8 g/l
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides (Publications)
N(1)-Phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (1) and N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites [...] potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N(1)-(3-hydroxy)phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (21) displays an IC(50) value of 260nM against African tr
Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland (Publications)
prevalences of C parvum, rotavirus, BCV and E coli k99 were 55.0 per cent, 58.7 per cent, 7.8 per cent and 5.5 per cent, respectively. The proportions of herds positive for the respective pathogens among the herds [...] 52.1 per cent, 2.1 per cent and 2.1 per cent. The immunoglobulin concentration in the serum of 90.5 per cent of the diarrhoeic calves was below 8 g/l
Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of <em>Triphyophyllum peltatum</em> (Dioncophyllaceae) and... (Publications)
Dioncoquinones A (4) and B (5) showed good - and specific - activity against Leishmania major, while they were not active against other protozoic parasites. Moreover, treatment with 4 and 5 strongly induced apoptosis [...] and Ancistrocladaceae seven new natural naphthoquinones were isolated, dioncoquinones A (4) and B (5) from Triphyophyllum peltatum, and ancistroquinones B (6), C (7), D (9), E (10), and F (12) from An
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides (Publications)
N(1)-Phenyl-3,5-dinitro-N(4),N(4)-di-n-propylsulfanilamide (1) and N(1)-phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites [...] potent compounds are rapidly degraded by rat liver S9 fractions in vitro, N(1)-(3-hydroxy)phenyl-3,5-dinitro-N(4),N(4)-di-n-butylsulfanilamide (21) displays an IC(50) value of 260nM against African tr
Comparative palatability of orally disintegrating tablets (ODTs) of praziquantel (L-PZQ and Rac-PZQ) versus current PZQ tablet in African children: a... (Publications)
analogue scale (VAS) incorporating a 5-point hedonic scale, immediately after spitting out the test product (VASt = 0 primary outcome) and after 2-5 minutes (VASt = 2-5). PRINCIPAL FINDINGS: In total, 48 [...] Higher VASt = 0 and VASt = 2-5 scores were reported for L-PZQ ODT compared with Rac-PZQ ODT in older children (p = 0.046 and p = 0.026, respectively). The VASt = 0 and VASt = 2-5 were higher for both ODT
Ambient air pollution exposure and depressive symptoms: findings from the French CONSTANCES cohort (Publications)
mean concentration of PM(2.5), BC and NO(2) were 17.14 microg/m(3) (IQR = 4.89), 1.82 10(-5)/m (IQR = 0.88) and 26.58 microg/m(3) (IQR = 17.41) respectively. Exposures to PM(2.5), BC and NO(2) were significantly [...] analyzed cross-sectionally. Annual concentrations of particulate matter with a diameter < 2.5 microm (PM(2.5)), black carbon (BC), and nitrogen dioxide (NO(2)) from the land-use regression models were
Research on the dynamic characteristics of indoor and outdoor environmental quality of office buildings based on long-term online monitoring of... (Publications)
summer > spring > autumn > winter, while the rank of indoor PM2.5 is winter > spring > autumn > summer. However, the outdoor humidity, outdoor PM2.5 and indoor and outdoor illumination, formaldehyde TVOC and [...] and variation characteristics of temperature, humidity, illumination, formaldehyde, TVOC, CO2 and PM2.5 in different floors of 6th, 9th, and 15th at different time scales. The results show that:① for the [...] then decreasing. In contrast, illumination shows a trend of first decreasing...
Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe (Publications)
from different exposure domains: air pollution (nitrogen dioxide (NO(2)), particulate matter < 2.5 mum (PM(2.5)), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and [...] was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM(2.5), NO(2) and BC) was associated with an increase in stroke incidence. For the built environment, higher [...] impervious surfaces were associated with a protective effect [%change in HR...