Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical... (Publications)
However, the optimal dose and duration are unknown. OBJECTIVE To investigate whether a short-term (5 days) systemic glucocorticoid treatment in patients with COPD exacerbation is noninferior to conventional [...] the Use of Corticosteroids in Exacerbated COPD), a randomized, noninferiority multicenter trial in 5 Swiss teaching hospitals, enrolling 314 patients presenting to the emergency department with acute COPD [...] March 2006 through February 2011. INTERVENTIONS Treatment with 40 mg of...
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical... (Publications)
However, the optimal dose and duration are unknown. OBJECTIVE To investigate whether a short-term (5 days) systemic glucocorticoid treatment in patients with COPD exacerbation is noninferior to conventional [...] the Use of Corticosteroids in Exacerbated COPD), a randomized, noninferiority multicenter trial in 5 Swiss teaching hospitals, enrolling 314 patients presenting to the emergency department with acute COPD [...] March 2006 through February 2011. INTERVENTIONS Treatment with 40 mg of...
Long-term effects of work cessation on respiratory health of textile workers: a 25-year follow-up study (Publications)
Spirometry testing and respiratory questionnaires were conducted at 5-year intervals. Generalized estimated equations were used to model the average 5-year change in FEV(1) and odds ratios of respiratory symptom [...] RESULTS: Years since cessation of textile work was positively associated with 11.3 ml/yr and 5.6 ml/yr gains in 5-year FEV(1) change for cotton and silk workers, respectively. Among male cotton workers, smokers
Deterrents to HIV-patient initiation of antiretroviral therapy in urban Lusaka, Zambia: a qualitative study (Publications)
were offered treatment but declined (n=37), ART staff (n=5), faith healers (n=5), herbal medicine providers (n=5), and home-based care providers (n=5). One focus group discussion with lay HIV counselors and
High prevalence of <em>Schistosoma haematobium</em> x <em>Schistosoma bovis</em> hybrids in schoolchildren in Côte d'Ivoire (Publications)
15 S. haematobium sequences (45.5%) belonging to seven haplotypes and 18 S. bovis sequences (54.5%) belonging to 12 haplotypes. Of 40 ITS 2 sequences analysed, 31 (77.5%) were assigned to pure S. haematobium [...] haematobium, four (10.0%) to pure S. bovis and five (12.5%) to S. haematobium-bovis hybrids. Our findings suggest that S. haematobium-bovis hybrids are common in Cote d'Ivoire. Hence, intense prospection of
Europe-wide air pollution modeling from 2000 to 2019 using geographically weighted regression (Publications)
58; PM10: 0.62; PM2.5: 0.77), which are better than SLR (average R(2) = NO2: 0.61; O3: 0.46; PM10: 0.51; PM2.5: 0.75) and RF (average R(2) = NO2: 0.64; O3: 0.53; PM10: 0.56; PM2.5: 0.67). The GTWR predictions [...] and random forest (RF). We built separate LUR models for each year from 2000 to 2019 for NO2, O3, PM2.5 and PM10 using annual average monitoring observations across Europe. Potential predictors included satellite
The prevalence of syphilis infection and its associated factors in the general population of Rwanda: a national household-based survey (Publications)
females was 5.9% (95% CI: 3.4-10.0). HIV-infected or concurrent sexual partners was associated with increased syphilis prevalence with aOR = 4.2 (95% CI: 2.5-7.2) and aOR = 4.2 (95% CI: 2.8-6.5), respectively [...] CI: 0.4-0.9)). Women with lower education had a higher prevalence of syphilis (1.2% (95% CI: 0.9-1.5)) compared to others (0.4% (95% CI: 0.2-0.8)). This prevalence among HIV-infected people was six times
Long-term associations of outdoor air pollution with mortality in Great Britain (Publications)
6% to 4.5%) per 10 microg/m(3) BS and 13.2% (95% CI 11.5% to 14.9%) per 10 ppb SO(2), and in the most recent period (1994-8) it was 19.3% (95% CI 5.1% to 35.7%) and 21.7% (95% CI 2.9% to 38.5%), respectively