Socio-environmental factors associated with the risk of contracting Buruli ulcer in Tiassalé, south Côte d'Ivoire: a case-control study (Publications)
(male:female) was 0.9. Median age was 25 years (range: 5-70 years). Regular contact with unprotected surface water (adjusted odds ratio (aOR) = 6.5; 95% confidence interval (CI) = 2.1-19.7) and absence [...] absence of protective equipment during agricultural activities (aOR = 18.5, 95% CI = 5.2-66.7) were identified as the main factors associated with the risk of contracting BU. Etiologic fractions among exposed [...] health centers of the district. Two controls were matched for each control,...
Representative seroprevalences of human and livestock brucellosis in two Mongolian provinces (Publications)
was 27.3% in humans (95% CI 23.7-31.2%), 6.2% (95% CI 5.5-7.1%) in sheep, 5.2% (95% CI 4.4-5.9%) in goats, 16.0% (95% CI 13.7-18.7%) in cattle, 2.5% (95% CI 0.8-7.6%) in camels, 8.3 (95% CI 6.0-11.6%) in
Seroprevalence and risk factors for Q fever and Rift Valley fever in pastoralists and their livestock in Afar, Ethiopia: a One Health approach (Publications)
highest seroprevalence (8.3%, 95%CI 3.3-19.2), followed by goats (2.7%; 95%CI 1.4-5.1), sheep (2.5%; 95%CI 1.0-5.9) and camels (1.8%; 95%CI 0.4-6.9). Human Q fever seropositivity was found to be associated [...] (95%CI 10.4-24.6) and 8.8% in cattle (95%CI 5.0-15.0). For Rift Valley fever the seroprevalence in pastoralists was 6.1% (95%CI 3.3-11.0) and 3.9% (95%CI 2.6-5.7) in livestock overall; cattle had the highest
Long-term exposure to ambient air pollution and risk of lung cancer: a comparative analysis of incidence and mortality in four administrative cohorts... (Publications)
respective meta-analytic HRs (95% CIs) of 1.14 (1.06, 1.22) and 1.12 (1.02, 1.22) per 5 μg/m(3) increase in PM(2.5), and 1.10 (1.04, 1.16) and 1.09 (1.02, 1.16) per 10 μg/m(3) increase in NO(2). Positive [...] Rome (2001-2015). We assessed residential exposure to annual average fine particulate matter (PM(2.5)), nitrogen dioxide (NO₂), black carbon (BC), and warm-season ozone (O(3)) using Europe-wide land use [...] 111,949 incident lung cancer cases occurred. Incident lung cancer was positively...
Ambient air pollution and hypertensive disorders of pregnancy in Rome (Publications)
were used to estimate the exposure to particulate matter (PM(2.5) and PM(10)), nitrogen dioxide (NO(2)), and ozone (O(3)). RESULTS: For PM(2.5,) PM(10) and NO(2), there was suggestive evidence of increased [...] hypertension (GH, n = 1901). For instance, an interquartile range of 7.0 μg/m(3) increase in PM(2.5) exposure during the first trimester of pregnancy was associated with an odds ratio (OR) of 1.06 (95% [...] NO(2) and the corresponding results for a 15.7 μg/m(3) increase in NO(2) after...
Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors (Publications)
at work OR 5.33, (1.57-18.0), OR 3.37 (1.04-10.87). Poultry farmers experienced the highest symptom rates. In crop farmers, the prevalence for chronic bronchitis was increased OR 2.32 (1.03-5.23). Over [...] (0.99-5.4) independent of the type of farming. The comparison of Swiss farmers with the Swiss population showed a twofold elevated risk of reporting chronic bronchitis OR 1.89 (1.32-2.95) and a 4.5-fold [...] 5-fold elevated risk for bringing up phlegm regularly OR 4.5 (3.25-6.69) in...
Understanding diarrhoeal diseases in response to climate variability and drought in Cape Town, South Africa: a mixed methods approach (Publications)
decreased over the decade studied, e.g. reduction of 64.7% in 2019 [95% confidence interval (CI): 5.5-7.2%] compared to 2010, with no increase during the severe drought period. Over the hot dry diarrhoeal [...] diarrhoea with dehydration incidence increased by 7.4% (95% CI: 4.5-10.3%) per 1 °C increase in temperature and 2.6% (95% CI: 1.7-3.5%) per 1% increase in relative humidity in the unlagged model. Stakeholder [...] METHODS: Using a mixed-methods approach, we explored diarrhoeal disease...
Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against <em>Haemophilus... (Publications)
pathway (C5) on both effector functions. Findings may be relevant for the treatment of certain diseases caused by dysregulation of the complement system, where inhibitors of complement factors C3 or C5 are used [...] vaccination significantly enhanced SBA titers. Independently of the vaccination status, both C3 and C5 inhibition abrogated SBA, whereas inhibition of the LP had no effect. AP inhibition had a major inhibitory [...] unmasked when bacterial killing by the membrane attack complex was...
Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate... (Publications)
and mortality register including nearly 5.5 million adults aged > /=30 (mean follow-up: 9.97 years). Annual mean concentrations for fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon [...] enhanced after further adjustment for NUTS-1 or NUTS-3. HRs for non-accidental mortality per 5 mug/m(3) increase for PM2.5 for the main model using hybrid LUR exposure were 1.023 (95%CI 1.011-1.035). After including
Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI (Publications)
diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a-c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines [...] vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a showed superior antitrypanosomal activity compared to that of the parent