Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI (Publications)
diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a-c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines [...] vitro against the protozoan parasite Trypanosoma brucei rhodesiense (T. b. r.). The thiophene analogue 5b and the N-methyl compound 15a showed superior antitrypanosomal activity compared to that of the parent
Long-term exposure to black carbon and mortality: a 28-year follow-up of the GAZEL cohort (Publications)
adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined [...] and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying
Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region (Publications)
children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p [...] communities in the Nelson Mandela Bay region. Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body
Consistency in preventing voluntary dehydration in boys who drink a flavored carbohydrate-NaCl beverage during exercise in the heat (Publications)
sessions (three 20-min cycling bouts at 50% VO2max with 5 min rest in between) over a 2-week period at 35 +/- 1 degrees C, 50 +/- 5% or 60 +/- 5% relative humidity. Subjects drank grape-flavored solution
Clonorchicidal properties of the synthetic trioxolane OZ78 (Publications)
mu g/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface [...] activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
brucei bloodstream forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialk [...] of visceral leishmaniasis and African trypanosomiasis, with 8,8-dimethyldihydroberberine chloride (5a) reducing liver parasitemia by 46% in L. donovani-infected BALB/c mice when given at an intraperitoneal
Clonorchicidal properties of the synthetic trioxolane OZ78 (Publications)
mu g/ml of OZ78. A single 300 mg/kg oral dose of OZ78 resulted in worm burden reductions of 78.5% and 98.5% against juvenile and adult C. sinensis, respectively. SEM observations revealed tegumental surface [...] activity against another liver fluke, namely Clonorchis sinensis. Rats infected with C. sinensis for 2 and 5 wk were treated orally with single doses of OZ78 (75, 150, or 300 mg/kg). Worm burden reductions were
Effects of Low-Level Air Pollution: A study in Europe (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/effects-of-low-level-air-pollution-a-study-in-europe
(> 35 million subjects). The analysis focuses on the pollutants PM2.5 (fine particles with an aerodynamic diameter of less than 2.5 μm), nitrogen dioxide (NO2), and ozone (O3), but also exploits the rich [...] collaboration in a research project Mortality and morbidity effects of long-term exposure to low-level PM2.5, Black Carbon, NO2 and O3: an analysis of European cohorts. The Project addresses the issue of health
Consistency in preventing voluntary dehydration in boys who drink a flavored carbohydrate-NaCl beverage during exercise in the heat (Publications)
sessions (three 20-min cycling bouts at 50% VO2max with 5 min rest in between) over a 2-week period at 35 +/- 1 degrees C, 50 +/- 5% or 60 +/- 5% relative humidity. Subjects drank grape-flavored solution
Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region (Publications)
children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p [...] communities in the Nelson Mandela Bay region. Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body
