Xenortide biosynthesis by entomopathogenic <em>Xenorhabdus nematophila</em> (Publications)
The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was
Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR (Publications)
In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antim
Simple analogues of Qinghaosu (Artemisinin) (Publications)
A series of 1,2,4-trioxanes were synthesized in which the key peroxy bonds were installed through a molybdenum-catalyzed perhydrolysis of the epoxy rings. A core structure was identified that may serv
Diagnosis of <em>Schistosoma haematobium </em>infection with a mobile phone-mounted foldscope and a reversed-lens CellScope in Ghana (Publications)
We evaluated two novel, portable microscopes and locally acquired, single-ply, paper towels as filter paper for the diagnosis of Schistosoma haematobium infection. The mobile phone-mounted Foldscope a
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
The quorum sensor and signalling molecule pyocyanin (PYO) contributes significantly to the pathophysiology of Pseudomonas aeruginosa infections. Comparison to phenothiazine drugs suggests that the ant
