Determinants of virological failure and antiretroviral drug resistance in Mozambique (Publications)
OBJECTIVES: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. METHODS: This was a cross-sectional study. HIV-1-infe
A global assessment of civil registration and vital statistics systems: monitoring data quality and progress (Publications)
Increasing demand for better quality data and more investment to strengthen civil registration and vital statistics (CRVS) systems will require increased emphasis on objective, comparable, cost-effect
Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness (Publications)
The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appear associated with greater epidemic potential. The mechanisms governing viral fitness in ep
Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
In our screening efforts to identify unique scaffolds from myxobacteria for the drug discovery process, we used LC-SPE-NMR-MS techniques to isolate six linear peptides, termed macyranone A-F, from Cys
Quantifying the health impacts of ambient air pollutants: recommendations of a WHO/Europe project (Publications)
OBJECTIVE: Quantitative estimates of air pollution health impacts have become an increasingly critical input to policy decisions. The WHO project "Health risks of air pollution in Europe-HRAPIE" was i
CCDC26, CDKN2BAS, RTEL1, and TERT polymorphisms in pediatric brain tumor susceptibility (Publications)
The role of genetic polymorphisms in pediatric brain tumor (PBT) etiology is poorly understood. We hypothesized that single nucleotide polymorphisms (SNPs) identified in genome-wide association studie
A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes (Publications)
Discovery of novel drug targets may lead to improved treatment of trypanosomiasis. We characterize here 2 gene products of Trypanosoma brucei that are essential for the growth of bloodstream form para
ARMADA: using motif activity dynamics to infer gene regulatory networks from gene expression data (Publications)
Analysis of gene expression data remains one of the most promising avenues toward reconstructing genome-wide gene regulatory networks. However, the large dimensionality of the problem prohibits the fi
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries (Publications)
The private for-profit sector is an important source of treatment for malaria. However, private patients face high prices for the recommended treatment for uncomplicated malaria, artemisinin combinati
Community awareness, use and preference for pandemic influenza vaccines in Pune, India (Publications)
Vaccination is a cornerstone of influenza prevention, but limited vaccine uptake was a problem worldwide during the 2009-2010 pandemic. Community acceptance of a vaccine is a critical determinant of i
