Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif (Publications)
To identify malaria antigens for vaccine development, we selected alpha-helical coiled coil domains of proteins predicted to be present in the parasite erythrocytic stage. The corresponding synthetic
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity
<em>Plasmodium falciparum</em>: malaria morbidity is associated with specific merozoite surface antigen 2 genotypes (Publications)
Plasmodium falciparum merozoite surface antigen 2 (MSA2) is considered a vaccine candidate in a subunit vaccine against blood stage malaria. In order to test if a specific genotype of the highly polym
The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
During the intra-erythrocytic development of Plasmodium falciparum, the parasite modifies the host cell surface by exporting proteins that interact with or insert into the erythrocyte membrane. These
Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against <em>Plasmodium falciparum</em> and <em>P. vivax malaria</em> in... (Publications)
Because of increasing resistance to 4-aminoquinolines in Papua New Guinea, combination therapy of amodiaquine (AQ) or chloroquine (CQ) plus sulfadoxine-pyrimethamine (SP) was introduced as first-line
