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1. Quinuclidine derivatives as potential antiparasitics (Publications)

   Quinuclidine derivatives as potential antiparasitics

   Pertinence:

   There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cau

2. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase (Publications)

   Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase

   Pertinence:

   There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a ver

3. Disentangling the impacts of seasonality, temperature and land cover on the abundance of arboviral mosquito vectors in California using generalized... (Publications)

   Disentangling the impacts of seasonality, temperature and land cover on the abundance of arboviral mosquito vectors in California using generalized additive models

   Pertinence:

4. Mode of action of action of Artemether/Iumefantirne (Coartem :the sole, fixed, oral ADDC) and its role in combatting multidrug-resistance (Publications)

   Mode of action of action of Artemether/Iumefantirne (Coartem :the sole, fixed, oral ADDC) and its role in combatting multidrug-resistance

   Pertinence:

5. Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment (Publications)

   Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment

   Pertinence:

   Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115) or three (n =

6. Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy:... (Publications)

   Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: <em>Plasmodium falciparum</em> dihydrofolate reductase and dihydropteroate synthase mutations in monitoring i

   Pertinence:

7. Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of <em>Plasmodium falciparum</em> malaria conducted... (Publications)

   Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of <em>Plasmodium falciparum</em> malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness.

   Pertinence:

8. Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood... (Publications)

   Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood cells

   Pertinence:

   Rosetting of Plasmodium falciparum-infected red blood cells (parasitized RBC [pRBC]) with uninfected RBC has been associated in many studies with malaria morbidity and is one form of cytoadherence obs

9. Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)

   Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

   Pertinence:

   Dihydrofolate reductase is a drug target that has not been thoroughly investigated in leishmania and trypanosomes. Work has previously shown that 5-benzyl-2,4-diaminopyrimidines are selective inhibito

10. Evidence of HLA class II association with antibody response against the malaria vaccine SPF66 in a naturally exposed population (Publications)

    Evidence of HLA class II association with antibody response against the malaria vaccine SPF66 in a naturally exposed population

    Pertinence:

    The antibody response against the malaria vaccine SPf66 and against circumsporozoite (CS) protein has been tested in immune adults from a malaria endemic area in Papua New Guinea. All individuals were